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An organ chip model of the mammalian joint
Unmet Need Human movement relies on the function of cartilage-containing joints. In conditions such as osteoarthritis (OA), the cartilage within the joints becomes inflamed and degrades, leading to intense debilitating pain when bending joints. Despite…
Biodegradable, elastomeric copolymers that can be used in continuous digital light processing 3D printing applications
Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 22.0% predicted to occur until 2024. Medical and dental products account for about…
A method for treating critical limb ischemia and other ischemic injuries
Unmet Need The most severe stage of peripheral artery disease, a chronic vascular disease characterized by impaired circulation to patients’ lower extremities, is critical limb ischemia (CLI), and it affects approximately two million people in…
An implanted biomaterial to accelerate bone healing
Unmet Need A leading concept in regenerative medicine is transplantation of tissue-specific cells, often supported with biomaterials, to promote tissue repair. While this strategy has achieved some success, its broad clinical application is hindered by…
Lowering ApoE to improve age-related bone fracture healing
Value Proposition Bone fractures occur in 50% of the population, causing significant morbidity and mortality and costing the US health care system over $20 billion annually. Complications, such as nonunion or delayed union, occur in…