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Extracellular vesicle biomarkers for detecting severity and progression of knee osteoarthritis

Extracellular vesicle biomarkers for detecting severity and progression of knee osteoarthritis

Unmet Need Osteoarthritis (OA) is a chronic degenerative joint disease that can impact the hands, knees, neck, lower back, and hips, leading to pain and restrictive mobility from the breakdown of connective tissue in these…

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Biodegradable, elastomeric copolymers that can be used in continuous digital light processing 3D printing applications

Biodegradable, elastomeric copolymers that can be used in continuous digital light processing 3D printing applications

Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 22.0% predicted to occur until 2024. Medical and dental products account for about…

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Detecting and predicting progression of osteoarthritis by biomarker analysis

Detecting and predicting progression of osteoarthritis by biomarker analysis

Unmet Need Osteoarthritis (OA) is a prevalent chronic disease that impacts 32.5 million US adults and hundreds of millions worldwide. Further, global incidence of OA is increasing due to rises in geriatric populations and other…

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Parametrization of fractal signature data

Parametrization of fractal signature data

The risk of knee osteoarthritis progression can be predicted from the subtle characteristics revealed on a knee radiograph of the subchondral bone, i.e. bone that underlies the articular cartilage. This technology is software code to…

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Clenbuterol Therapy for Amyotrophic Lateral Sclerosis

Clenbuterol Therapy for Amyotrophic Lateral Sclerosis

Unmet Need Amyotrophic lateral sclerosis (ALS) is a debilitating disease with progressive loss of muscle function and inevitable death usually in 3-5 years. There are currently two available therapies on the market which prolong life…

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A method for treating critical limb ischemia and other ischemic injuries

A method for treating critical limb ischemia and other ischemic injuries

Unmet Need The most severe stage of peripheral artery disease, a chronic vascular disease characterized by impaired circulation to patients’ lower extremities, is critical limb ischemia (CLI), and it affects approximately two million people in…

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An implanted biomaterial to accelerate bone healing

An implanted biomaterial to accelerate bone healing

Unmet Need A leading concept in regenerative medicine is transplantation of tissue-specific cells, often supported with biomaterials, to promote tissue repair. While this strategy has achieved some success, its broad clinical application is hindered by…

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Predicting progression of osteoarthritis by feature analysis of bone radiographs

Predicting progression of osteoarthritis by feature analysis of bone radiographs

Unmet Need Osteoarthritis (OA) is a leading cause of disability among adults, it currently affects more than 27 million Americans and more than 300 million individuals worldwide. Currently, there are no validated predictors of OA…

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CaMKK2 as target for Hematopoietic Stem Cell regeneration

CaMKK2 as target for Hematopoietic Stem Cell regeneration

Unmet Need Stem cell research and medicine in recent years has yielded various therapies for the treatment of numerous diseases. Hematopoietic stem and progenitor cells (HSPC) are found in both the bone marrow and blood…

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One-Thing-Straight: A mobile application-based technology for improving the posture of individuals with Parkinson’s Disease

One-Thing-Straight: A mobile application-based technology for improving the posture of individuals with Parkinson’s Disease

Value Proposition Parkinson’s Disease (PD) affects over six hundred thousand Americans, and these individuals often have a forward flexed, or bent posture. However, patients often have the musculoskeletal ability to improve their posture but lack…

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Novel dystonia treatment drugs

Novel dystonia treatment drugs

Value Proposition Dystonia is a movement disorder characterized by sustained, often painful involuntary postures, causing motor disabilities and a marked decrease in quality of life. Dystonia is the third most common movement disorder behind Parkinson’s…

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Improving osteoarthritis treatment through facilitated transport of bisphosphonates to chondrocytes by vitamin C

Improving osteoarthritis treatment through facilitated transport of bisphosphonates to chondrocytes by vitamin C

Value Proposition Osteoarthritis is the most prevalent of all forms of arthritis and the second greatest cause of disability worldwide. The Centers for Disease Control and Prevention estimates that osteoarthritis affects over 30 million adults…

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