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Spine Secure’s Non-Invasive Halo
Unmet Need Globally, over 15 million people are living with spinal cord injury as of 2021. Based on data from 2019, 0.9 million new cases emerged in a year. While most cases are due to…
An organ chip model of the mammalian joint
Unmet Need Human movement relies on the function of cartilage-containing joints. In conditions such as osteoarthritis (OA), the cartilage within the joints becomes inflamed and degrades, leading to intense debilitating pain when bending joints. Despite…
Lightweight, portable wearable device for passive hand and wrist rehabilitation with adjustable therapy settings
Unmet Need Stroke, a prevalent cerebrovascular disease affecting 7.8 million patients in the US, often leaves survivors with hemiparesis, impacting the upper extremity on one side. About 85% of stroke patients experience reduced hand motor…
Extracellular vesicle biomarkers for detecting severity and progression of knee osteoarthritis
Unmet Need Osteoarthritis (OA) is a chronic degenerative joint disease that can impact the hands, knees, neck, lower back, and hips, leading to pain and restrictive mobility from the breakdown of connective tissue in these…
Biodegradable, elastomeric copolymers that can be used in continuous digital light processing 3D printing applications
Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 22.0% predicted to occur until 2024. Medical and dental products account for about…
Detecting and predicting progression of osteoarthritis by biomarker analysis
Unmet Need Osteoarthritis (OA) is a prevalent chronic disease that impacts 32.5 million US adults and hundreds of millions worldwide. Further, global incidence of OA is increasing due to rises in geriatric populations and other…
Parametrization of fractal signature data
The risk of knee osteoarthritis progression can be predicted from the subtle characteristics revealed on a knee radiograph of the subchondral bone, i.e. bone that underlies the articular cartilage. This technology is software code to…
Clenbuterol Therapy for Amyotrophic Lateral Sclerosis
Unmet Need Amyotrophic lateral sclerosis (ALS) is a debilitating disease with progressive loss of muscle function and inevitable death usually in 3-5 years. There are currently two available therapies on the market which prolong life…
A method for treating critical limb ischemia and other ischemic injuries
Unmet Need The most severe stage of peripheral artery disease, a chronic vascular disease characterized by impaired circulation to patients’ lower extremities, is critical limb ischemia (CLI), and it affects approximately two million people in…
An implanted biomaterial to accelerate bone healing
Unmet Need A leading concept in regenerative medicine is transplantation of tissue-specific cells, often supported with biomaterials, to promote tissue repair. While this strategy has achieved some success, its broad clinical application is hindered by…
Lowering ApoE to improve age-related bone fracture healing
Value Proposition Bone fractures occur in 50% of the population, causing significant morbidity and mortality and costing the US health care system over $20 billion annually. Complications, such as nonunion or delayed union, occur in…
CaMKK2 as target for Hematopoietic Stem Cell regeneration
Unmet Need Stem cell research and medicine in recent years has yielded various therapies for the treatment of numerous diseases. Hematopoietic stem and progenitor cells (HSPC) are found in both the bone marrow and blood…