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An injectable hydrogel scaffold that delivers gene therapies locally
Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…
A CRISPR-based system for modifying the length of 3’ untranslated regions (3’UTR) of an mRNA transcript that offers novel treatment strategies for prostate cancer and other diseases
Unmet Need Abnormal length changes in the 3’ untranslated region (3’UTR) of mRNAs are associated with many diseases such as systemic lupus erythematosus, α-thalassemia, facioscapulohumeral muscular dystrophy, and cancer. While existing technologies can manipulate expression…
Mining microbial genomes for biologically active compounds
Most microbes of importance to human and environmental health are not amenable to experimentation. As a result, we do not know what molecules these microbes use to manipulate their environment- many of which are likely…
A universal antidote for aptamer therapeutics
Value Proposition With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to…
A software for more easily monitoring physiological data through improved visualization and machine learning analysis
Value Proposition With inexpensive wearable sensors, physiological data monitoring has extended beyond clinical anesthesia and emergency medicine and into in-home healthcare. Waveforms such as electrocardiography (ECG) and photoplethysmography (PPG) contain valuable information about a patient’s…