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LpxH targeting antibiotics for Gram-negative bacteria
Unmet Need Antimicrobial resistance of bacteria to antibiotics is a major threat to public health. In 2019, 4.95 million deaths, 64% of all bacterial infection related deaths globally, were attributed to antimicrobial resistance to antibiotics.…
Small molecules that target RNA structures within the CoV genome
Unmet Need SARS-CoV-2 is the etiological agent of the COVID-19 respiratory disease, the largest scale respiratory virus pandemic the world has witnessed since the 1918 Spanish flu and that has claimed more than 1.4 million…
Small molecules that can safely exploit copper as an antimicrobial
Value Proposition The fungal pathogen Cryptococcus neoformans can live in both plants and animals, but when inhaled by humans can disseminate from the lungs to the bloodstream and cause life-threatening systemic disease. The brain is…
Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury
Value Proposition Damage to the lung epithelium in response to pathogens is a major health problem worldwide. Parenchymal lung infections disrupt lung epithelial architecture and function by eliciting destruction of airway and alveolar cell populations.…
Novel small molecule mast cell activator vaccine adjuvants
Value Proposition Mast cells (MCs) are innate immune cells highly prevalent in the dermal region of the skin and in the respiratory, gastrointestinal, and urinary tract mucosa. The strategic location at the host–environment interface and…
Compositions and methods for treating gram-negative bacterial infection
Value Proposition Antimicrobial resistance is considered to be one of the biggest crises facing modern medicine today. Without desperately needed intervention, it is estimated that by 2050 over 10 million deaths per year will be…