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Replication competent bi- and tri-valent influenza viruses as vaccines
Value Proposition Influenza infection is a major public health concern, with an estimated 200,000 Americans hospitalized each year with flu or flu-related illness. The most effective method for flu prevention is vaccination, however, due to…
Molecular classifiers of bacterial infection
Disclosed herein are biomarkers useful for identifying and/or classifying bacterial infections in a subject.
APOE polymorphisms associated with SEPSIS risk
Duke University is seeking a company interested in commercializing a novel and versatile diagnostic/prognostic methodology which teaches identifying a patient who will have a post operative reduced risk of sepsis based on the pre-op detection…
Mast cell targeting to predict and prevent virus-induced vascular leakage
Value Proposition Dengue is a mosquito spread virus that affects millions of people worldwide. According to the World Health Organization, there are approximately 390 million dengue virus infections each year, and it is the leading…
Compositions and methods for treating gram-negative bacterial infection
Value Proposition Antimicrobial resistance is considered to be one of the biggest crises facing modern medicine today. Without desperately needed intervention, it is estimated that by 2050 over 10 million deaths per year will be…
Antibodies for the detection of Ebola virus infection
Value Proposition Ebola Virus Disease (EVD) is a severe, often fatal illness in humans caused by one of five different Ebola viruses. The virus is transmitted to people from wild animals and spreads in the…
Gene expression signature to predict sepsis mortality
Improved risk stratification and prognosis in sepsis is a critical unmet need. Clinical severity scores and available assays such as blood lactate reflect global illness severity with suboptimal performance, and do not specifically reveal the…
Viral microRNAs expressed in cells latently infected with Herpes Simplex Virus Type 1
The present invention relates, in general, to micro RN As and, in particular, to viral microRNAs expressed by Herpes Simplex Vims 1 (HSV-1) or Herpes Simplex Virus 2 (HSV-2), to agents that inhibit such microRNAs…