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Small molecules that can safely exploit copper as an antimicrobial
Value Proposition The fungal pathogen Cryptococcus neoformans can live in both plants and animals, but when inhaled by humans can disseminate from the lungs to the bloodstream and cause life-threatening systemic disease. The brain is…
Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury
Value Proposition Damage to the lung epithelium in response to pathogens is a major health problem worldwide. Parenchymal lung infections disrupt lung epithelial architecture and function by eliciting destruction of airway and alveolar cell populations.…
Intubation tent to protect healthcare workers from infected patients
Value Proposition Under the current COVID crisis, health care workers need protection against respiratory infections transmitted by patients undergoing treatment. Patients undergoing intubation for surgery or prior to being placed on a ventilator can expose…
Strengthening a patient’s immune functions to prevent infectious diseases without developing antibiotic resistance
Unmet Need Despite the development of numerous antibiotics over the years, the arms race between humans and emergent antibiotic-resistant microbes remains. More than 2.8 million antibiotic-resistant infections and 35,000 deaths occur in the U.S. each…
Novel small molecule mast cell activator vaccine adjuvants
Value Proposition Mast cells (MCs) are innate immune cells highly prevalent in the dermal region of the skin and in the respiratory, gastrointestinal, and urinary tract mucosa. The strategic location at the host–environment interface and…
Molecular diagnostic test for acute respiratory viral infections
Unmet Need Acute respiratory viral (ARV) infections are among the most common reasons for patient visits in primary and acute care settings. ARV can be caused by many viruses including human rhinovirus (HRV), respiratory syncytial…
Novel class of antibiotics effective against drug-resistant bacteria
Unmet Need Antimicrobial resistance among Gram-negative bacilli is increasing and becoming alarmingly common, especially as bacterial strains become resistant to multiple antibiotics. The infectious diseases caused by multidrug-resistant bacteria pose serious threats to humankind. There…
Structural analogues of N-pyridin-4-yl-1,3-benzothiazole-6-carboxamide as lead compounds for preventing or treating urinary tract infections
Value Proposition Uropathogenic Escherichia coli (UPEC) is the leading cause of community-acquired urinary tract infections (UTIs). Over 100 million UTIs occur annually throughout the world, including more than 7 million cases in U.S. adolescents and…
![Structural analogues of 3- [(2,6-difluorobenzoyl)amino]-5-(4-ethoxyphenyl)thiophene-2-carboxylic acid as lead compounds for preventing or treating urinary tract infections](https://innovate.olv.duke.edu/scripts/renderPublicFile.php?filePath=3/forms/7787/20200424160743_5ea3470f72ae4/bacteria-in-a-blue-background-3d-illustration-PRXXYT3.jpg "Structural analogues of 3- [(2,6-difluorobenzoyl)amino]-5-(4-ethoxyphenyl)thiophene-2-carboxylic acid as lead compounds for preventing or treating urinary tract infections")
Structural analogues of 3- [(2,6-difluorobenzoyl)amino]-5-(4-ethoxyphenyl)thiophene-2-carboxylic acid as lead compounds for preventing or treating urinary tract infections
Value Proposition Uropathogenic Escherichia coli (UPEC) is the leading cause of community-acquired urinary tract infections (UTIs). Over 100 million UTIs occur annually throughout the world, including more than 7 million cases in U.S. adolescents and…
Inactivating viral replication with CRISPR/Cas systems
Value Proposition Current gene therapy approaches based upon targeted DNA endoculeases, such as zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), are based upon custom built DNA binding domains. Although gene therapy with…
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A therapeutic vaccine platform for treating influenza viruses
Value Proposition Influenza virus infections represent a substantial global burden on human health. Each year, it is estimated that influenza viruses cause up to 5 million severe infections globally, resulting in up to 645,000 mortalities.…
Device for personalizing ventilation settings on a shared system
Value Proposition In times of emergency, multiple patients might require to be supported on the same ventilator system. However, patients might have different degrees of lung function, including lung compliance and required volumes of support.…