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Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development
Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…
Enhancing immune responses in a variety of applications with a lymph node targeting biodegradable nanoparticle
Unmet Need While vaccines have resulted in plummeting mortality rates in the human population over the last century, significant challenges remain for which current vaccine formulations fall short. For example, current influenza vaccines are unable…
Peptide materials for immunomodulation
Value Proposition Glatiramoids are biomaterials synthesized for use as immunomodulators. Specifically, they are polypeptide mixtures with randomized amino acid sequences. Glatiramoids are currently FDA approved for use in multiple sclerosis. They have also been explored…
Sublingual immunization using supramolecular peptide-polymer conjugate tablets
Value proposition Immunization with vaccines prevent illness, disability, and currently avert an estimated 2 to 3 million deaths every year. However, commonly-used vaccine technology platforms can be unpredictable, require a high manufacturing cost, and often…