Skip to main content
A novel T-cell-based immunotherapy for brain cancer

A novel T-cell-based immunotherapy for brain cancer

Unmet Need Cancer immunotherapy represents a new paradigm in cancer treatment with the goal of harnessing the immune system to selectively attack a patient’s tumor. T-cell-based immunotherapies encompass chimeric antigen receptor (CAR)-T cells, tumor-infiltrating lymphocytes,…

Read More

PD-L1-Based Therapy for Non-Opioid Treatment of Chronic Pain

PD-L1-Based Therapy for Non-Opioid Treatment of Chronic Pain

Unmet Need Chronic pain, including inflammatory, neuropathic, and cancer-related pain, remains difficult to manage without opioids, which pose risks of addiction and adverse side effects. Existing non-opioid treatments often fail to provide sufficient relief or…

Read More

Probiotic-based prevention of respiratory infections

Probiotic-based prevention of respiratory infections

Unmet Need Pneumonia is the leading infectious killer of children, causing over 800,000 deaths annually. Streptococcus pneumoniae remains a major driver of these fatalities, even with widespread vaccination. Current vaccines are insufficient to address all…

Read More

Method for immune tolerance induction in patients receiving enzyme replacement therapy for a variety of metabolic disorders

Method for immune tolerance induction in patients receiving enzyme replacement therapy for a variety of metabolic disorders

Unmet Need Genetically based metabolic disorders affect 1 in 2500 births globally and many of these disorders result in an enzyme deficiency. In most cases, a single enzyme is not produced by the body at…

Read More

Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development

Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development

Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…

Read More

Functionalized microfiber mesh for inflammation and thrombosis prevention

Functionalized microfiber mesh for inflammation and thrombosis prevention

Unmet Need Trauma is a significant global health issue responsible for approximately 10% of deaths and over 15% of disabilities worldwide according to the World Health Organization. In addition to physical injuries, trauma-induced inflammation plays…

Read More

Method to overcome treatment resistant cancer by rescuing STING signaling

Method to overcome treatment resistant cancer by rescuing STING signaling

Unmet Need Among types of brain cancer, glioblastoma (GBM) is the most common and the most devastating. Over 8000 patients are diagnosed annually in the United States, accounting for half of all primary malignant brain…

Read More

Universal Antibodies Effective Against Both Influenza A and B

Universal Antibodies Effective Against Both Influenza A and B

Unmet Need Distinct influenza A and B viruses (IAV and IBV) circulate in human populations, causing significant widespread morbidity. Antibodies (Abs) that bind epitopes conserved in both IAV and IBV hemagglutinins (HAs) could protect against…

Read More

Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Unmet Need Venous thrombosis/thromboembolism (VT/E), the formation of a blood clot in vein, can be a life-threatening condition with 600,000 incidences in the US per year and affecting an estimated 10 million people globally. VT/E…

Read More

RXR modulators to improve the efficacy of immunomodulatory agents in multiple myeloma treatment

RXR modulators to improve the efficacy of immunomodulatory agents in multiple myeloma treatment

Unmet Need Multiple myeloma (MM) is the second most common hematological malignancy in the United States. Although current anti-myeloma therapeutics help patients live with the disease for more than 10 years, MM remains an incurable…

Read More

Leukocyte phenotyping methods to provide prognostic information and risk/resilience stratification for surgical procedures and critical illness

Leukocyte phenotyping methods to provide prognostic information and risk/resilience stratification for surgical procedures and critical illness

Unmet Need It is estimated that surgical complications arise in 16.4%, or almost 1 in 6 surgical procedures in the United States. Most complications have an immunological basis related to infection or aberrant adaptation to…

Read More

A tool to facilitate high affinity binding between beta-Arrestin and GPCR

A tool to facilitate high affinity binding between beta-Arrestin and GPCR

Unmet Need Beta-arrestins are a highly conserved family of cytosolic adaptor proteins that contribute to a multitude of physiological functions through a canonical interaction with various G protein-coupled receptors (GPCRs). Through agonist binding to GPCRs,…

Read More

Have Questions?

Please contact us or subscribe for more opportunities

Stay in Touch with Us