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A method for treating pain and inflammation using GPR37 agonists
Unmet Need Uncontrolled inflammation is a prominent component of many common diseases and is the root cause of chronic pain. When inflammation persists, the inflammatory factors are never completely cleared from the system, leading to…
A new method for treating chronic pain including cancer pain
Unmet Need According to the CDC, chronic pain has been linked to numerous physical and mental conditions and contributes to high health care costs and low productivity. Available studies estimate that the prevalence of chronic…
Enhancing immune responses in a variety of applications with a lymph node targeting biodegradable nanoparticle
Unmet Need While vaccines have resulted in plummeting mortality rates in the human population over the last century, significant challenges remain for which current vaccine formulations fall short. For example, current influenza vaccines are unable…
Peptide materials for immunomodulation
Value Proposition Glatiramoids are biomaterials synthesized for use as immunomodulators. Specifically, they are polypeptide mixtures with randomized amino acid sequences. Glatiramoids are currently FDA approved for use in multiple sclerosis. They have also been explored…
Strengthening a patient’s immune functions to prevent infectious diseases without developing antibiotic resistance
Unmet Need Despite the development of numerous antibiotics over the years, the arms race between humans and emergent antibiotic-resistant microbes remains. More than 2.8 million antibiotic-resistant infections and 35,000 deaths occur in the U.S. each…
Novel small molecule mast cell activator vaccine adjuvants
Value Proposition Mast cells (MCs) are innate immune cells highly prevalent in the dermal region of the skin and in the respiratory, gastrointestinal, and urinary tract mucosa. The strategic location at the host–environment interface and…
Sublingual immunization using supramolecular peptide-polymer conjugate tablets
Value proposition Immunization with vaccines prevent illness, disability, and currently avert an estimated 2 to 3 million deaths every year. However, commonly-used vaccine technology platforms can be unpredictable, require a high manufacturing cost, and often…
Beta-arrestin inhibition to prevent S1P1 internalization as a treatment for intracranial diseases
Value Proposition Glioblastomas (GBMs) are among the most common and deadly malignant brain tumors with a mean survival time of approximately 14-15 months following diagnosis. Current treatments for GBMs include surgery, radiation, and chemotherapy, however,…
Methods for treating pain and predicting cancer immune therapy efficacy
Value proposition Chronic pain is a major health problem that affects approximately 1.5 billion people worldwide. The annual economic cost of chronic pain in the United States, including both treatment and lost productivity is estimated…
Components of the Wnt-Beta-catenin paracrine signaling pathway as predictive biomarkers for cancer immunotherapy
Value Proposition Immunotherapy is a promising approach for the treatment of many cancers. However, despite early success, majority of patients with advanced cancer fail to respond or become resistant. In even the most immunogenic cancer…
Ex vivo scavenging of pro-inflammatory nucleic acids by electrospun cationic nanofibers
Value proposition Chronic wounds are a challenge to treat and consume a great deal of healthcare resources around the globe. In the setting of chronic wounds, dead and dying cells are continuously releasing nucleic acids…
Inhibition of endosomal TLR-activation with nucleic acid binding polymers
Value Proposition Inflammatory and autoimmune diseases are the result of improper activation of the immune system, and can have chronic debilitating effects on quality of life. This inflammation is mediated by pattern recognition receptors (PRRs)…