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Perfusate for optimized gene delivery to donor organs undergoing ex vivo machine perfusion

Perfusate for optimized gene delivery to donor organs undergoing ex vivo machine perfusion

Unmet Need Effective gene delivery is notoriously difficult to achieve to an entire target organ. Gene therapies have traditionally been administered intravascularly, requiring high vector doses to attain therapeutic levels of expression. Because of this…

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Targeted delivery of gene therapy for cardiac reprogramming with enhanced efficacy

Targeted delivery of gene therapy for cardiac reprogramming with enhanced efficacy

Unmet Need Cardiac injury results in irreversible and permanent loss of cardiomyocytes, leading to heart failure with ~40% mortality within 4 years from diagnosis. It has been shown that directly reprogramming scar fibroblasts into new…

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