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A simple blood test that can predict heart failure earlier than current methods
Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…
A humanized pro-N-cadherin antibody that can be used for treating and predicting heart failure
Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…
Algorithm for improving the clarity of electrocardiograms for patients with LVADs
Unmet Need Electrocardiogram (ECG) measurements are an important tool for monitoring patient heart health and can detect issues related to arrythmias, heart attacks, and cardiomyopathy. Heart health is especially important to monitor in patients who…
Genomic predictors of mortality following heart surgery
Unmet Need Several models have been developed to estimate the risk of mortality following cardiac surgery, including the European System for Cardiac Operative Risk Evaluation (EuroSCORE), but they all are limited in their ability to…
Metabolite biomarkers of human heart failure
Value Proposition Heart failure is a very common condition affecting approximately 5.1 million people in the United States. Due to its association with age, the incidence of heart failure, as well as the cost of…
Mast cell targeting to predict and prevent virus-induced vascular leakage
Value Proposition Dengue is a mosquito spread virus that affects millions of people worldwide. According to the World Health Organization, there are approximately 390 million dengue virus infections each year, and it is the leading…
Biomarkers to measure patient platelet functional status on aspirin and predict cardiovascular events
Value Proposition Aspirin is the most commonly prescribed anti-platelet medication for prevention of acute coronary syndrome (ACS), which continues to be the leading cause of morbidity and mortality in the U.S. Aspirin has long been…