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Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Unmet Need Venous thrombosis/thromboembolism (VT/E), the formation of a blood clot in vein, can be a life-threatening condition with 600,000 incidences in the US per year and affecting an estimated 10 million people globally. VT/E…

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Clinically-Linked ECG and Arrhythmia Repository (CLEAR)

Clinically-Linked ECG and Arrhythmia Repository (CLEAR)

Invention Summary Duke inventors have developed a database of digital 12- lead ECG samples that represent key rhythms of cardiac disorders. Each patient’s disorder was validated by a licensed and board-certified cardiovascular medicine physician to…

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Bacterial voltage gated ion channels for cardiac reprogramming

Bacterial voltage gated ion channels for cardiac reprogramming

Unmet Need Untreated cardiovascular disease (CVD) can lead to irreversible heart damage. This occurs when ischemia — inadequate blood flow — leads to the death of heart muscle fibers that conduct electrical impulses. Consequently, scar…

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Targeted delivery of gene therapy for cardiac reprogramming with enhanced efficacy

Targeted delivery of gene therapy for cardiac reprogramming with enhanced efficacy

Unmet Need Cardiac injury results in irreversible and permanent loss of cardiomyocytes, leading to heart failure with ~40% mortality within 4 years from diagnosis. It has been shown that directly reprogramming scar fibroblasts into new…

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A microscopy method for acquiring polarization-sensitive phase information in 3D

A microscopy method for acquiring polarization-sensitive phase information in 3D

Unmet Need The majority of biological research and clinical diagnostics has involved the use of optical imaging systems for transparent specimens that rely on scalar properties like phase contrast. These systems have proved useful for…

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Transcriptional alterations during blood storage to monitor stored red cells and reduce storage-lesions

Transcriptional alterations during blood storage to monitor stored red cells and reduce storage-lesions

Unmet Need Currently, red blood cell (RBC) testing focuses on factors such as hemoglobin content, RBC count, blood typing, and antibody content. These tests, though comprehensive, do not measure the health and quality of RBCs.…

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Transgenic zebrafish to direct epicardial gene expression

Transgenic zebrafish to direct epicardial gene expression

Technology Duke inventors have generated a novel zebrafish model that allows researchers to study epicardial cells during embryonic heart development and myocardial regeneration. This zebrafish line is termed Tg(tcf21:CreER)pd42. Specifically, this transgenic model was created…

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iPSC line to identify novel therapies for ARVC

iPSC line to identify novel therapies for ARVC

Technology Duke inventors have developed a novel induced pluripotent stem cell (iPSC) line that contains a mutation that impacts the TAX1BP3 gene, which causes arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC). Specifically, the iPSCs were derived from…

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Human B2-adrenergic receptor CHW cell line

Human B2-adrenergic receptor CHW cell line

Technology Duke inventors have generated a chinese hamster fibroblast cell line that expresses the human β2–adrenegic receptor.

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Long extra-corporeal arterial sheaths and catheters for coronary angiography and intervention

Long extra-corporeal arterial sheaths and catheters for coronary angiography and intervention

Value Proposition Percutaneous coronary interventions (PCI) such as angioplasty and angiography can be performed for therapeutic as well as diagnostic reasons. Over 20 million angiography and 10 million angioplasty procedures are projected to be performed…

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Connecting cardiac and respiratory 3DCT imaging for 5DCT heart motion management

Connecting cardiac and respiratory 3DCT imaging for 5DCT heart motion management

Unmet Need Ventricular tachycardia (VT) is a primary condition of heart disease noted as an irregularity of heart rhythm due to improper electrical signaling in the ventricles that causes an abnormally high heart rate. VT…

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WireCleat – Fully safe Seldinger Technique device for prevention of guide wire retention

WireCleat – Fully safe Seldinger Technique device for prevention of guide wire retention

Unmet Need Catheters are widely used in many medical disciplines as a means of gaining easy access to internal body cavities like blood vessels or hollow organs. The Seldinger technique is a common method for…

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