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Transcatheter device for restricting blood flow through the pulmonary artery
Unmet Need In the United States, approximately 10,000 newborns a year will require surgery for a congenital heart defect such as atrial or ventricular septal defects. These defects can cause excessive blood flow to the…
Blood pressure control by gene editing
Unmet Need The World Health Organization estimates that high blood pressure (hypertension) results in approximately 9 million annual deaths worldwide. Currently available drugs used to control blood pressure can be effective but are limited by…
Rapid application of portable tourniquet for use in junctional regions
Unmet Need There is a need for easy to use, efficient and cost-effective tourniquets for hard to isolate areas such as junctional regions of the body, areas that are not suitable for application of circumferential…
A novel acoustic biomarker for quality of life in LVAD recipients
Unmet Need Left ventricular devices (LVADs) are surgically implanted pumps that improve survival in patients with advanced heart failure. According to St. Judes, in the U.S. in 2016, over 7% of LVAD users reported poor…
A signal processing algorithm to mitigate LVAD noise in sound recording of LVAD recipients
Unmet Need Left ventricular devices (LVADs) are surgically implanted pumps that improve survival in patients with advanced heart failure. While lifesaving, LVAD therapy is also associated with high morbidity, in part due to difficulties identifying…
Aptamer anticoagulant therapy to reduce complications of ECMO treatment
Unmet Need Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment for critically ill patients with low oxygen levels. During ECMO, the patient’s blood flows through an external oxygenation device. This requires co-treatment with an anticoagulant…
Near-infrared fluorescent proteins for live cell and animal imaging
Unmet Need Fluorescent microscopy is one of the most common research tools used by biologists and has a global market value expected to exceed $768 million by 2023. Many of the currently available fluorescent protein…
A method for treating critical limb ischemia and other ischemic injuries
Unmet Need The most severe stage of peripheral artery disease, a chronic vascular disease characterized by impaired circulation to patients’ lower extremities, is critical limb ischemia (CLI), and it affects approximately two million people in…
Virtual frequency-selective inversion method for fat suppression in MRI
Unmet Need In magnetic resonance imaging (MRI), data is acquired by a scanner that sends a sequence of radio frequency (RF) pulses into the tissue placed in a strong magnetic field. The magnetic field causes…
A high-speed echocardiographic system that can assess cardiac function in real-time
Unmet Need Since its inception in the mid-1970s, real-time echocardiography employing phased array principles has had a significant impact on the practice of medicine particularly in cardiology. The real-time or live nature of image formation…
Harvis: an interactive virtual reality tool for modification and simulation of blood flow
Unmet Need Cardiovascular disease (CVD) is the largest underlying cause of mortality in the United States, causing one in every three deaths and costing an estimated $316 billion dollars a year. In recent years, computational…
A low-cost test for patients to self-monitor prothrombin time at home
Unmet Need Heart failure affects over 6.4 million individuals in the US, with over 550,000 new cases emerging annually. A large fraction of these cases requires long-term use of ventricular assist devices that necessitate the…