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Harvis: an interactive virtual reality tool for modification and simulation of blood flow
Unmet Need Cardiovascular disease (CVD) is the largest underlying cause of mortality in the United States, causing one in every three deaths and costing an estimated $316 billion dollars a year. In recent years, computational…
A low-cost test for patients to self-monitor prothrombin time at home
Unmet Need Heart failure affects over 6.4 million individuals in the US, with over 550,000 new cases emerging annually. A large fraction of these cases requires long-term use of ventricular assist devices that necessitate the…
Cardiac rhythm interpretation flipbook
Unmet Need Nurses caring for patients who require ECG monitoring are trained in rhythm interpretation in order to identify normal and abnormal cardiac conditions and to apply appropriate therapeutic interventions. However, studies have shown a…
A new method to improve contrast-enhanced MRI by suppressing blood pool signal
Unmet Need In magnetic resonance imaging (MRI), contrast agents are often used to enhance the difference between diseased and normal tissue. Images taken with contrast agents allow to identify myocardial infarction, stroke, tumors, atherosclerosis, tissue…
Single-cardiac-cycle phase sensitive inversion recovery (PSIR) method for cardiac MRI
Unmet Need Magnetic Resonance Imaging (MRI) is a safe, non-invasive test that creates detailed images of organs and tissues. In a typical MRI procedure, the subject is positioned in a strong magnetic field, and the…
Treating and reducing cardiac dysfunction with bisphosphonate compositions by increasing the phosphorylation of kinases in heart tissue
Value Proposition The prevalence of heart failure (“HF”) has grown to epidemic proportions as the population ages. HF may be caused by many forms of heart disease. Each of these disease processes can lead to…
Treating heart failure with bisphosphonate compositions
Value Proposition The prevalence of heart failure (“HF”) has grown to epidemic proportions as the population ages and as cardiologists have become more successful at reducing mortality from ischemic heart disease, the most common prelude…
A simple metabolomic profile to predict risk of subsequent cardiovascular events
Value Proposition Coronary artery disease (CAD) is the leading cause of death in industrialized countries, and in concert with the epidemic of obesity and diabetes, is rapidly becoming the leading cause of death in developing…
Peripherally Inserted Left Ventricular Vent and Anticoagulation System (PILVAS)
Value Proposition Extra-corporeal membrane oxygenation (ECMO) support is a rapidly growing technique to treat patients in severe cardiac distress. As its use increases, incidence of the common complications of support, including significant bleeding, stroke, infection,…
Algorithm for improving the clarity of electrocardiograms for patients with LVADs
Unmet Need Electrocardiogram (ECG) measurements are an important tool for monitoring patient heart health and can detect issues related to arrythmias, heart attacks, and cardiomyopathy. Heart health is especially important to monitor in patients who…
Genomic predictors of mortality following heart surgery
Unmet Need Several models have been developed to estimate the risk of mortality following cardiac surgery, including the European System for Cardiac Operative Risk Evaluation (EuroSCORE), but they all are limited in their ability to…
Gene polymorphisms to identify altered effectiveness of beta blocker therapy in cardiac surgery candidates
Unmet Need Postoperative atrial fibrillation (AF) is the most common complication following the coronary artery bypass graft surgery (CABG), occurring in 20% to 40% of patients. Studies indicate that postoperative AF is associated with an…