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Algorithm for improving the clarity of electrocardiograms for patients with LVADs
Unmet Need Electrocardiogram (ECG) measurements are an important tool for monitoring patient heart health and can detect issues related to arrythmias, heart attacks, and cardiomyopathy. Heart health is especially important to monitor in patients who…
Gene polymorphisms to identify altered effectiveness of beta blocker therapy in cardiac surgery candidates
Unmet Need Postoperative atrial fibrillation (AF) is the most common complication following the coronary artery bypass graft surgery (CABG), occurring in 20% to 40% of patients. Studies indicate that postoperative AF is associated with an…
Genomic predictors of mortality following heart surgery
Unmet Need Several models have been developed to estimate the risk of mortality following cardiac surgery, including the European System for Cardiac Operative Risk Evaluation (EuroSCORE), but they all are limited in their ability to…
Metabolite biomarkers of human heart failure
Value Proposition Heart failure is a very common condition affecting approximately 5.1 million people in the United States. Due to its association with age, the incidence of heart failure, as well as the cost of…
T2-preparation optimized for cardiac imaging
Value Proposition Myocardial infarction is the leading cause of death in the United States. T2-imaging of the heart is used to detect areas of myocardial edema which may aid in the diagnosis of myocardial infarction.…
An algorithm for improving tissue ablation accuracy in the treatment of atrial fibrillation
Value Proposition Irregular and rapid heartbeat, commonly referred to as atrial fibrillation, is the most prevalent form of heart disease. The poor blood flow resulting from atrial fibrillation can cause short breath, weakness, and even…
A software for more easily monitoring physiological data through improved visualization and machine learning analysis
Value Proposition With inexpensive wearable sensors, physiological data monitoring has extended beyond clinical anesthesia and emergency medicine and into in-home healthcare. Waveforms such as electrocardiography (ECG) and photoplethysmography (PPG) contain valuable information about a patient’s…
C-nitroso donors of neutral nitric oxide to treat hypertension and other diseases
Value proposition Hypertension, also known as high blood pressure, can lead to severe complications and increase the risk of heart disease, stroke, and death. About 1 out of 3 US adults, or about 75 million…
Stem cell-derived factors for treating pathologic conditions
1.3 million Americans experience a heart attack (acute myocardial infarction or AMI) each year. A significant percentage of these patients die from restricted blood flow to the heart (ischemia) and significant loss of cardiac function.…
Mast cell targeting to predict and prevent virus-induced vascular leakage
Value Proposition Dengue is a mosquito spread virus that affects millions of people worldwide. According to the World Health Organization, there are approximately 390 million dengue virus infections each year, and it is the leading…
Novel AnnexinA1 tripeptide (ANXA1sp) improves acute kidney injury after deep hypothermic circulatory arrest
Value Proposition Heart disease is the leading cause of death in industrialized nations across the world, with treatments often requiring surgery such as coronary artery bypass graft (CABG) or even transplantation. Although cardiac surgery is…
RNA Aptamers Targeting a coagulation Cascade Cofactor
Value Proposition Thrombosis (blood clots within blood vessels) is a major underlying factor in many cardiovascular diseases and a major source for complications following hospital stays and surgeries. Venous thrombosis occurs in approximately 1 per…