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A humanized pro-N-cadherin antibody that can be used for treating and predicting heart failure

A humanized pro-N-cadherin antibody that can be used for treating and predicting heart failure

Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…

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Gene therapy for non-alcoholic steatohepatitis and associated liver fibrosis

Gene therapy for non-alcoholic steatohepatitis and associated liver fibrosis

Unmet Need Driven by the rising tide of obesity and lack of medical treatment, it is estimated that 1 out of 4 adults in the US has non-alcoholic fatty liver disease or non-alcoholic steatohepatitis (NAFLD/NASH).…

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A device for clinical wet-to-wet connections that alleviates healthcare provider anxiety and enhances patient quality of care

A device for clinical wet-to-wet connections that alleviates healthcare provider anxiety and enhances patient quality of care

Unmet Need Extracorporeal membrane oxygenation (ECMO) is a rapidly growing method of providing life-saving support to a patient suffering from heart or lung failure. Between 2010 and 2021 ECMO runs in the United States grew…

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Transcatheter device for restricting blood flow through the pulmonary artery

Transcatheter device for restricting blood flow through the pulmonary artery

Unmet Need In the United States, approximately 10,000 newborns a year will require surgery for a congenital heart defect such as atrial or ventricular septal defects. These defects can cause excessive blood flow to the…

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Blood pressure control by gene editing

Blood pressure control by gene editing

Unmet Need The World Health Organization estimates that high blood pressure (hypertension) results in approximately 9 million annual deaths worldwide. Currently available drugs used to control blood pressure can be effective but are limited by…

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Rapid application of portable tourniquet for use in junctional regions

Rapid application of portable tourniquet for use in junctional regions

Unmet Need There is a need for easy to use, efficient and cost-effective tourniquets for hard to isolate areas such as junctional regions of the body, areas that are not suitable for application of circumferential…

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A novel acoustic biomarker for quality of life in LVAD recipients

A novel acoustic biomarker for quality of life in LVAD recipients

Unmet Need Left ventricular devices (LVADs) are surgically implanted pumps that improve survival in patients with advanced heart failure. According to St. Judes, in the U.S. in 2016, over 7% of LVAD users reported poor…

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A signal processing algorithm to mitigate LVAD noise in sound recording of LVAD recipients

A signal processing algorithm to mitigate LVAD noise in sound recording of LVAD recipients

Unmet Need Left ventricular devices (LVADs) are surgically implanted pumps that improve survival in patients with advanced heart failure. While lifesaving, LVAD therapy is also associated with high morbidity, in part due to difficulties identifying…

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Aptamer anticoagulant therapy to reduce complications of ECMO treatment

Aptamer anticoagulant therapy to reduce complications of ECMO treatment

Unmet Need Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment for critically ill patients with low oxygen levels. During ECMO, the patient’s blood flows through an external oxygenation device. This requires co-treatment with an anticoagulant…

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A method for treating critical limb ischemia and other ischemic injuries

A method for treating critical limb ischemia and other ischemic injuries

Unmet Need The most severe stage of peripheral artery disease, a chronic vascular disease characterized by impaired circulation to patients’ lower extremities, is critical limb ischemia (CLI), and it affects approximately two million people in…

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Virtual frequency-selective inversion method for fat suppression in MRI

Virtual frequency-selective inversion method for fat suppression in MRI

Unmet Need In magnetic resonance imaging (MRI), data is acquired by a scanner that sends a sequence of radio frequency (RF) pulses into the tissue placed in a strong magnetic field. The magnetic field causes…

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A high-speed echocardiographic system that can assess cardiac function in real-time

A high-speed echocardiographic system that can assess cardiac function in real-time

Unmet Need Since its inception in the mid-1970s, real-time echocardiography employing phased array principles has had a significant impact on the practice of medicine particularly in cardiology. The real-time or live nature of image formation…

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