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Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism

Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism

Unmet Need 1 in 3 adults in the United States have a form of metabolic dysregulation, including diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). While these metabolic diseases range…

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The Fit Together Playbook: a curriculum that fosters community partnerships to fight child obesity

The Fit Together Playbook: a curriculum that fosters community partnerships to fight child obesity

Unmet Need Childhood obesity affects 1 in 5 children resulting in more than 14.7 million obese children ages 2-19 years old in the United States. Many factors can contribute and cause obesity including diet, lack…

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RXR modulators to improve the efficacy of immunomodulatory agents in multiple myeloma treatment

RXR modulators to improve the efficacy of immunomodulatory agents in multiple myeloma treatment

Unmet Need Multiple myeloma (MM) is the second most common hematological malignancy in the United States. Although current anti-myeloma therapeutics help patients live with the disease for more than 10 years, MM remains an incurable…

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Pancreatic cancer treatment that inhibits the Piezo1/TRPV4 axis

Pancreatic cancer treatment that inhibits the Piezo1/TRPV4 axis

Unmet Need Pancreatic cancer has one of the highest mortality rates of all cancer types in the US. The American Cancer Society predicts that about 64,000 people will be diagnosed with pancreatic cancer and 55,000…

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A functionally selective ghrelin receptor (GHSR) ligand for treatment of chemical and food addiction

A functionally selective ghrelin receptor (GHSR) ligand for treatment of chemical and food addiction

Unmet Need The number of Americans with addiction-related disorders, including substance use disorders (SUD) and food addiction is increasing rapidly each year. Recent estimates indicate that >20 million people in the U.S. have been diagnosed…

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The ubiquitination status of the glucagon receptor determines signal bias

The ubiquitination status of the glucagon receptor determines signal bias

Unmet Need Currently, management of diabetes and other metabolic disorders lacks understanding of how the ubiquitination status of the glucagon receptor (GCGR) impacts its signaling pathways. Conventional approaches in targeting G protein-coupled receptors (GPCRs) for…

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Gene therapy for non-alcoholic steatohepatitis and associated liver fibrosis

Gene therapy for non-alcoholic steatohepatitis and associated liver fibrosis

Unmet Need Driven by the rising tide of obesity and lack of medical treatment, it is estimated that 1 out of 4 adults in the US has non-alcoholic fatty liver disease or non-alcoholic steatohepatitis (NAFLD/NASH).…

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Treating the brain from the gut

Treating the brain from the gut

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Dual agonist proteins for the treatment of type 2 diabetes

Dual agonist proteins for the treatment of type 2 diabetes

Unmet Need Over 37 million people in the United States have diabetes, and approximately 90-95% of them have type 2 diabetes (T2D). Diabetes and its related complications not only cause premature mortality and lower quality…

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A method to optimize neural activity blocking therapies

A method to optimize neural activity blocking therapies

Unmet Need The use of kilohertz frequency (KHF) as neuromodulatory therapies that block unwanted neural activity have been applied to treat chronic pain, phantom limb pain, obesity, and other applications. However, the high energy demands…

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The Trail Guide curriculum for childhood obesity treatment program model

The Trail Guide curriculum for childhood obesity treatment program model

Unmet Need Childhood obesity is an ongoing health concern involving cardiometabolic risk, reduced quality of life and long-term health consequences. Current child obesity treatment guidelines recommend 26 or more hours of behavior treatment, delivered over…

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A method of screening and monitoring glycogen storage diseases with a single biomarker

A method of screening and monitoring glycogen storage diseases with a single biomarker

Unmet Need Glycogen storage disease type I (GSD I) is an autosomal recessive inherited disorder of carbohydrate metabolism associated with life threatening fasting hypoglycemia, and significant morbidity and mortality. Currently, the standard of care therapy…

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