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The Fit Together Playbook: a curriculum that fosters community partnerships to fight child obesity
Unmet Need Childhood obesity affects 1 in 5 children resulting in more than 14.7 million obese children ages 2-19 years old in the United States. Many factors can contribute and cause obesity including diet, lack…
RXR modulators to improve the efficacy of immunomodulatory agents in multiple myeloma treatment
Unmet Need Multiple myeloma (MM) is the second most common hematological malignancy in the United States. Although current anti-myeloma therapeutics help patients live with the disease for more than 10 years, MM remains an incurable…
Pancreatic cancer treatment that inhibits the Piezo1/TRPV4 axis
Unmet Need Pancreatic cancer has one of the highest mortality rates of all cancer types in the US. The American Cancer Society predicts that about 64,000 people will be diagnosed with pancreatic cancer and 55,000…
A functionally selective ghrelin receptor (GHSR) ligand for treatment of chemical and food addiction
Unmet Need The number of Americans with addiction-related disorders, including substance use disorders (SUD) and food addiction is increasing rapidly each year. Recent estimates indicate that >20 million people in the U.S. have been diagnosed…
The ubiquitination status of the glucagon receptor determines signal bias
Unmet Need Currently, management of diabetes and other metabolic disorders lacks understanding of how the ubiquitination status of the glucagon receptor (GCGR) impacts its signaling pathways. Conventional approaches in targeting G protein-coupled receptors (GPCRs) for…
Gene therapy for non-alcoholic steatohepatitis and associated liver fibrosis
Unmet Need Driven by the rising tide of obesity and lack of medical treatment, it is estimated that 1 out of 4 adults in the US has non-alcoholic fatty liver disease or non-alcoholic steatohepatitis (NAFLD/NASH).…
Dual agonist proteins for the treatment of type 2 diabetes
Unmet Need Over 37 million people in the United States have diabetes, and approximately 90-95% of them have type 2 diabetes (T2D). Diabetes and its related complications not only cause premature mortality and lower quality…
A method to optimize neural activity blocking therapies
Unmet Need The use of kilohertz frequency (KHF) as neuromodulatory therapies that block unwanted neural activity have been applied to treat chronic pain, phantom limb pain, obesity, and other applications. However, the high energy demands…
The Trail Guide curriculum for childhood obesity treatment program model
Unmet Need Childhood obesity is an ongoing health concern involving cardiometabolic risk, reduced quality of life and long-term health consequences. Current child obesity treatment guidelines recommend 26 or more hours of behavior treatment, delivered over…
A method of screening and monitoring glycogen storage diseases with a single biomarker
Unmet Need Glycogen storage disease type I (GSD I) is an autosomal recessive inherited disorder of carbohydrate metabolism associated with life threatening fasting hypoglycemia, and significant morbidity and mortality. Currently, the standard of care therapy…
A target for identifying and treating metabolic diseases including insulin resistance
Unmet Need The World Health Organization attributes over 70% of all deaths globally to noncommunicable diseases (NCD) including cardiovascular disease, diabetes, and cancer. Risk factors for NCDs include obesity, raised blood pressure, and the regional…