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Non-opioid treatment for chronic pain using a neurotensin receptor 1 modulator
Unmet Need For individuals experiencing chronic pain, day-to-day tasks and activities can become difficult or impossible. It can also lead to other long-term health challenges including insomnia, stress, anxiety, and depression. Chronic pain is so…
Use of rifaximin and bacterial strains for treating probable neurodegenerative disorders like Alzheimer’s Disease
Unmet Need There is an urgent need to develop novel therapies for neurodegenerative diseases and conditions such as Alzheimer's disease (AD). Ten percent of people over age 65 and up to 50% over age 85…
Clenbuterol Therapy for Amyotrophic Lateral Sclerosis
Unmet Need Amyotrophic lateral sclerosis (ALS) is a debilitating disease with progressive loss of muscle function and inevitable death usually in 3-5 years. There are currently two available therapies on the market which prolong life…
Method for treatment of dementia associated with Alzheimer’s disease and other neurodegenerative diseases
Unmet Need There are over 50 million people worldwide with dementia, with about 10 million new cases diagnosed every year. Though approximately 70% of dementia cases are associated with Alzheimer's disease patients, there is no…
New selective small molecule inhibitors for the treatment of pain and itch
Unmet Need In the United States, an estimated 50 million adults suffer from chronic pain and around 20 million adults suffer from high-impact chronic pain. Ongoing difficulty in safely treating pain has led to the…
Novel iron chelators that protect cells from oxidative stress
Unmet Need Metal ions play important roles in the proper functioning of any living organism, but pathologies can develop when metal homeostasis is disturbed. Too much loosely bound iron produces “reactive oxygen species” (ROS) that…
Novel drugs for the treatment of dystonia
Value Proposition Dystonia is a classification of rare and debilitating movement disorders, for which there exists few therapeutic options. Treatments include therapy with botulinum neurotoxin to induce paralysis or deep brain stimulation. Not only are…
Beta-arrestin inhibition to prevent S1P1 internalization as a treatment for intracranial diseases
Value Proposition Glioblastomas (GBMs) are among the most common and deadly malignant brain tumors with a mean survival time of approximately 14-15 months following diagnosis. Current treatments for GBMs include surgery, radiation, and chemotherapy, however,…
Novel dystonia treatment drugs
Value Proposition Dystonia is a movement disorder characterized by sustained, often painful involuntary postures, causing motor disabilities and a marked decrease in quality of life. Dystonia is the third most common movement disorder behind Parkinson’s…
Conjugated neuroactive steroid compositions and methods of use thereof
The present disclosure provides modified neuroactive steroids. The modified neuroactive steroids may comprise, consist of, or consist essentially of a therapeutic agent and/or a modifying moiety. The modified neuroactive steroid can have modified characteristics as…