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Viral-mediated humanized mouse model for Parkinson’s disease

Viral-mediated humanized mouse model for Parkinson’s disease

Unmet Need Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the midbrain and the accumulation of α-synuclein aggregates (Lewy bodies), leading to motor and cognitive impairments. PD…

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Novel Self-Assembling Nanoparticles for Extended Duration Local Anesthetics

Novel Self-Assembling Nanoparticles for Extended Duration Local Anesthetics

Unmet Need An estimated 40 million surgeries are performed every year in the United States. Out of this population, an estimated 80% had post-operative pain with 75% reporting it as moderate to extreme. Local anesthetics…

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Olfactory neuroblastoma mouse model

Olfactory neuroblastoma mouse model

Unmet Need Olfactory neuroblasoma (ONB) is an agressive tumor that is thought to arise in basal stem cells in the adult olfactory epithelium. This rare cancer affects 1 in 2.5 million people each year with…

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Mouse model of Alzheimer’s disease

Mouse model of Alzheimer’s disease

Unmet Need Alzheimer’s disease is a neurodegenerative disease marked by loss of cognitive function. There is currently no cure for Alzheimer’s disease. In fact, the limited therapies available only alleviate symptoms for a short time…

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Mouse model of cholinergic dysfunction to evaluate cognitive enhancers for Alzheimer’s disease treatment

Mouse model of cholinergic dysfunction to evaluate cognitive enhancers for Alzheimer’s disease treatment

Value Proposition Defects in acetylcholine transmission have been associated with several major neurodegenerative disorders including Alzheimer’s disease, dementia, cerebral palsy, Parkinson’s disease, Huntington’s disease and myasthenia gravis. Although cholinergic dysfunction has been implicated in these…

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Shank3 knockout mice as a model for autism

Shank3 knockout mice as a model for autism

The Shank3B- knockout allele has a neo cassette replacing the PDZ domain (exons 13-16) of the Shank3 gene, resulting altered expression of the Shank3b isoform. These mice may be useful for studying behavioral abnormalities associated…

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