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A method for selectively blocking nerve fibers during neurostimulation treatment using kilohertz frequency electrical signals
Unmet Need In the past three decades implanted neurostimulation devices have become widely adopted driven largely by their ability to treat a range of clinical conditions with a “drug-free” solution. The $6.6 billion dollar market…
Implant for identifying sites of seizure onset in the brain
Unmet Need In the United States, epilepsy affects 2.2 million people with 150,000 new cases each year. Between 14.6% and 36.3% of people who suffer from epilepsy have forms of epilepsy that are not controllable…
A method to improve deep brain stimulation treatments by using cortical evoked potentials as a biomarker
Unmet Need Neuromodulation therapies are used to treat a wide variety of clinical conditions. For example, an estimated 150,000 deep brain stimulation (DBS) implants are performed globally to help treat movement disorders like Parkinson’s Disease.…
A multi-electrode multiplexed channel brain-computer interface for patient assistive technologies
Unmet Need According to the WHO, in 2019 neurological disorders were recognized as a growing public health challenge resulting in over 500,000 deaths globally. In the US alone, neurological diseases cause an estimated $800 billion-dollar…
Surgical device to insert graft between skull and dura
Unmet Need About 16,000 patients per year are diagnosed with a mastoid space defect. This is a defect in the skull that leads to hearing loss caused by cerebrospinal fluid leaking into the mastoid space,…
Genetically encoded neuronal electrophysiology
Unmet Need An essential part of studying the brain is understanding how a symphony of neurons activate together, as a circuit, to carry out specific functions. Studying these circuits sheds valuable insight into healthy neurons…
Engineered conductive polymer for neural activity recording
Unmet Need Dysfunctions in neural circuit activity underlie complex psychiatric diseases such as depression, schizophrenia, Alzheimer’s disease, and others. Neural activity recording is critical to understand brain function and how aberrations in neural circuits lead…
Improved beta oscillation burst detection for assessment of Parkinson’s disease
Unmet Need Parkinson’s disease is a debilitating ailment, though therapies such as deep brain stimulation via electrodes can improve symptoms. Such therapies rely on feedback from biomarkers to adjust the stimulation parameters. Such biomarkers may…
Method to optimize spinal cord stimulation therapy placement and parameters
Unmet Need Spinal cord stimulation (SCS) is an FDA approved therapy that stimulates the spinal cord using electrical pulses. This therapy is used to treat chronic pain, and it is estimated 50,000 spinal cord stimulating…
A method to optimize neural activity blocking therapies
Unmet Need The use of kilohertz frequency (KHF) as neuromodulatory therapies that block unwanted neural activity have been applied to treat chronic pain, phantom limb pain, obesity, and other applications. However, the high energy demands…
Flexible needle for targeted delivery of chronic pain treatment
Unmet Need For patients suffering from chronic pain associated with degenerative changes, inflammation, neuropathy or cancer, the ability to carry out daily life and work activities is a challenge. Current treatment methods are limited and…
Adjustable tubular retractor for brain surgery
Unmet Need In 2018 the Journal of Neurosurgery estimated that there were 22.6 million patients globally suffering from neurological disorders, with 13.8 million of them requiring surgery. During intracranial operations concerning aneurysms, tumor extractions, and…