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A method for selectively blocking nerve fibers during neurostimulation treatment using kilohertz frequency electrical signals
Unmet Need In the past three decades implanted neurostimulation devices have become widely adopted driven largely by their ability to treat a range of clinical conditions with a “drug-free” solution. The $6.6 billion dollar market…
Implant for identifying sites of seizure onset in the brain
Unmet Need In the United States, epilepsy affects 2.2 million people with 150,000 new cases each year. Between 14.6% and 36.3% of people who suffer from epilepsy have forms of epilepsy that are not controllable…
A method to improve deep brain stimulation treatments by using cortical evoked potentials as a biomarker
Unmet Need Neuromodulation therapies are used to treat a wide variety of clinical conditions. For example, an estimated 150,000 deep brain stimulation (DBS) implants are performed globally to help treat movement disorders like Parkinson’s Disease.…
A multi-electrode multiplexed channel brain-computer interface for patient assistive technologies
Unmet Need According to the WHO, in 2019 neurological disorders were recognized as a growing public health challenge resulting in over 500,000 deaths globally. In the US alone, neurological diseases cause an estimated $800 billion-dollar…
Improved beta oscillation burst detection for assessment of Parkinson’s disease
Unmet Need Parkinson’s disease is a debilitating ailment, though therapies such as deep brain stimulation via electrodes can improve symptoms. Such therapies rely on feedback from biomarkers to adjust the stimulation parameters. Such biomarkers may…
Method to optimize spinal cord stimulation therapy placement and parameters
Unmet Need Spinal cord stimulation (SCS) is an FDA approved therapy that stimulates the spinal cord using electrical pulses. This therapy is used to treat chronic pain, and it is estimated 50,000 spinal cord stimulating…
A method to optimize neural activity blocking therapies
Unmet Need The use of kilohertz frequency (KHF) as neuromodulatory therapies that block unwanted neural activity have been applied to treat chronic pain, phantom limb pain, obesity, and other applications. However, the high energy demands…
A method to improve the clinical utility of kilohertz frequency alternating current devices to treat neurological disorders
Unmet Need Many neurological disorders, including pain and spasticity, are characterized by undesirable increases in sensory, motor, or autonomic nerve activity. Local application of kilohertz frequency alternating currents (KHFAC) can effectively and completely block the…
An injectable hydrogel scaffold that delivers gene therapies locally
Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…
An optimization method for spinal cord stimulation electrodes
Unmet Need Spinal cord stimulation is a trusted and proven treatment for patients with chronic pain, and spinal cord stimulator devices are implanted in 34,000 patients a year. Electrical stimulation is delivered via an implanted…
Method of deep brain stimulation for use in treating Parkinson’s Disease
Value Proposition Parkinson’s disease is a common neurodegenerative disorder that progressively deteriorates the motor system. With over seven million people afflicted globally and a rising incidence rate, improved treatment options for Parkinsonian symptoms will be…
Model-based optimization of spinal cord stimulation parameters
Value Proposition Spinal cord stimulation (SCS) is an FDA approved therapy for treating chronic lower back and limb pain. SCS is based on the gate control theory of pain, where an implanted pulse generator delivers…