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Olfactory neuroblastoma mouse model
Unmet Need Olfactory neuroblasoma (ONB) is an agressive tumor that is thought to arise in basal stem cells in the adult olfactory epithelium. This rare cancer affects 1 in 2.5 million people each year with…
Method to overcome treatment resistant cancer by rescuing STING signaling
Unmet Need Among types of brain cancer, glioblastoma (GBM) is the most common and the most devastating. Over 8000 patients are diagnosed annually in the United States, accounting for half of all primary malignant brain…
Gene therapy and small molecule treatment of chronic pain without addiction
Unmet Need Chronic pain is an escalating issue worldwide – in the U.S., an estimated one of five adults are affected. Chronic pain is difficult to treat, often requiring powerful opioids to provide relief. These…
A new method for treating chronic pain including cancer pain
Unmet Need According to the CDC, chronic pain has been linked to numerous physical and mental conditions and contributes to high health care costs and low productivity. Available studies estimate that the prevalence of chronic…
Beta-arrestin inhibition to prevent S1P1 internalization as a treatment for intracranial diseases
Value Proposition Glioblastomas (GBMs) are among the most common and deadly malignant brain tumors with a mean survival time of approximately 14-15 months following diagnosis. Current treatments for GBMs include surgery, radiation, and chemotherapy, however,…