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Treating the brain from the gut

Treating the brain from the gut

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A tool to facilitate high affinity binding between beta-Arrestin and GPCR

A tool to facilitate high affinity binding between beta-Arrestin and GPCR

Unmet Need Beta-arrestins are a highly conserved family of cytosolic adaptor proteins that contribute to a multitude of physiological functions through a canonical interaction with various G protein-coupled receptors (GPCRs). Through agonist binding to GPCRs,…

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A method to optimize neural activity blocking therapies

A method to optimize neural activity blocking therapies

Unmet Need The use of kilohertz frequency (KHF) as neuromodulatory therapies that block unwanted neural activity have been applied to treat chronic pain, phantom limb pain, obesity, and other applications. However, the high energy demands…

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Flexible needle for targeted delivery of chronic pain treatment

Flexible needle for targeted delivery of chronic pain treatment

Unmet Need For patients suffering from chronic pain associated with degenerative changes, inflammation, neuropathy or cancer, the ability to carry out daily life and work activities is a challenge. Current treatment methods are limited and…

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Gene therapy and small molecule treatment of chronic pain without addiction

Gene therapy and small molecule treatment of chronic pain without addiction

Unmet Need Chronic pain is an escalating issue worldwide – in the U.S., an estimated one of five adults are affected. Chronic pain is difficult to treat, often requiring powerful opioids to provide relief. These…

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A stable, easily manufactured intranasal oxytocin formulation that contains only food grade preservatives

A stable, easily manufactured intranasal oxytocin formulation that contains only food grade preservatives

Unmet Need Current formulations of oxytocin used for the treatment of neuropsychiatric disorders have several drawbacks. For example, many intravenous and intranasal formulations, like those approved in Europe, contain preservatives like chlorobutanol which is highly…

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An injectable hydrogel scaffold that delivers gene therapies locally

An injectable hydrogel scaffold that delivers gene therapies locally

Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…

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