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Improved beta oscillation burst detection for assessment of Parkinson’s disease
Unmet Need Parkinson’s disease is a debilitating ailment, though therapies such as deep brain stimulation via electrodes can improve symptoms. Such therapies rely on feedback from biomarkers to adjust the stimulation parameters. Such biomarkers may…
Systems and methods for efficient prediction and design of neural stimulation
Unmet Need Bioelectronic therapy is the ability to deliver various electrical impulses to patients through implanted medical devices. These devices can treat heart failure, epilepsy, and chronic pain among other ailments. Depending on the disease,…
Signals for onset-free conduction block
Unmet Need Neuromodulation and neurostimulation devices are used to control the responses of the nervous system and alleviate disease. Delivering to a nerve an alternating current at a high frequency can produce a nerve block…
TRPV4 ion channels as a target in systemic pruritic diseases
Unmet Need Pruritus, or an itching sensation, is one common symptom shared by hepatobiliary diseases, intrahepatic cholestasis of pregnancy (between 0.2% of 2% of all pregnancies) chronic kidney disease (55% prevalence globally), and pruritic psoriasis.…
The Delirium Care Process Model: An interactive flowchart to standardize and inform delirium diagnosis and care
Unmet Need In the United States, the geriatric population was estimated to be about 55.8 million in 2020, comprising 17% of the total population. The size of this population is only expected to increase as…
Olfactory neuroblastoma mouse model
Unmet Need Olfactory neuroblasoma (ONB) is an agressive tumor that is thought to arise in basal stem cells in the adult olfactory epithelium. This rare cancer affects 1 in 2.5 million people each year with…
Methods to utilize microbial organisms in the gut to modulate neurological responses
Unmet Need The gut is home to dynamic bacterial communities that shape the behavior of the host. The food we eat, our changes in mood, and even some of our social behaviors correlate with shifts…
Method for streamlining deep brain stimulation control parameters determination in Parkinson’s Disease
Unmet Need Parkinson’s disease (PD) is estimated to impact 10 million people worldwide. Currently, there are no cures for the disease. While treatments have significantly improved symptoms in patients, side effects of the pharmaceutical treatments…
A method for selectively blocking nerve fibers during neurostimulation treatment using kilohertz frequency electrical signals
Unmet Need In the past three decades implanted neurostimulation devices have become widely adopted driven largely by their ability to treat a range of clinical conditions with a “drug-free” solution. The $6.6 billion dollar market…
Implant for identifying sites of seizure onset in the brain
Unmet Need In the United States, epilepsy affects 2.2 million people with 150,000 new cases each year. Between 14.6% and 36.3% of people who suffer from epilepsy have forms of epilepsy that are not controllable…
Method to overcome treatment resistant cancer by rescuing STING signaling
Unmet Need Among types of brain cancer, glioblastoma (GBM) is the most common and the most devastating. Over 8000 patients are diagnosed annually in the United States, accounting for half of all primary malignant brain…
A method to enable the use of a novel biomarker for deep brain stimulation treatments
Unmet Need Neuromodulation therapies are used to treat a wide variety of clinical conditions. For example, an estimated 150,000 deep brain stimulation (DBS) implants are performed globally to help treat movement disorders like Parkinson’s Disease.…