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Non-invasive method to predict rates of post-operative cognitive problems

Non-invasive method to predict rates of post-operative cognitive problems

Unmet Need Older adults are at a higher risk of cognitive dysfunction after surgery, with postoperative delirium (POD) being the most common disorder. POD is characterized by inattentiveness and is seen in 70-80% of intensive…

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Improved beta oscillation burst detection for assessment of Parkinson’s disease

Improved beta oscillation burst detection for assessment of Parkinson’s disease

Unmet Need Parkinson’s disease is a debilitating ailment, though therapies such as deep brain stimulation via electrodes can improve symptoms. Such therapies rely on feedback from biomarkers to adjust the stimulation parameters. Such biomarkers may…

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Signals for onset-free conduction block

Signals for onset-free conduction block

Unmet Need Neuromodulation and neurostimulation devices are used to control the responses of the nervous system and alleviate disease. Delivering to a nerve an alternating current at a high frequency can produce a nerve block…

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Systems and methods for efficient prediction and design of neural stimulation

Systems and methods for efficient prediction and design of neural stimulation

Unmet Need Bioelectronic therapy is the ability to deliver various electrical impulses to patients through implanted medical devices. These devices can treat heart failure, epilepsy, and chronic pain among other ailments. Depending on the disease,…

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The Delirium Care Process Model: An interactive flowchart to standardize and inform delirium diagnosis and care

The Delirium Care Process Model: An interactive flowchart to standardize and inform delirium diagnosis and care

Unmet Need In the United States, the geriatric population was estimated to be about 55.8 million in 2020, comprising 17% of the total population. The size of this population is only expected to increase as…

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Olfactory neuroblastoma mouse model

Olfactory neuroblastoma mouse model

Unmet Need Olfactory neuroblasoma (ONB) is an agressive tumor that is thought to arise in basal stem cells in the adult olfactory epithelium. This rare cancer affects 1 in 2.5 million people each year with…

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Methods to utilize microbial organisms in the gut to modulate neurological responses

Methods to utilize microbial organisms in the gut to modulate neurological responses

Unmet Need The gut is home to dynamic bacterial communities that shape the behavior of the host. The food we eat, our changes in mood, and even some of our social behaviors correlate with shifts…

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A method for selectively blocking nerve fibers during neurostimulation treatment using kilohertz frequency electrical signals

A method for selectively blocking nerve fibers during neurostimulation treatment using kilohertz frequency electrical signals

Unmet Need In the past three decades implanted neurostimulation devices have become widely adopted driven largely by their ability to treat a range of clinical conditions with a “drug-free” solution. The $6.6 billion dollar market…

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Implant for identifying sites of seizure onset in the brain

Implant for identifying sites of seizure onset in the brain

Unmet Need In the United States, epilepsy affects 2.2 million people with 150,000 new cases each year. Between 14.6% and 36.3% of people who suffer from epilepsy have forms of epilepsy that are not controllable…

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Method to overcome treatment resistant cancer by rescuing STING signaling

Method to overcome treatment resistant cancer by rescuing STING signaling

Unmet Need Among types of brain cancer, glioblastoma (GBM) is the most common and the most devastating. Over 8000 patients are diagnosed annually in the United States, accounting for half of all primary malignant brain…

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A method to enable the use of a novel biomarker for deep brain stimulation treatments

A method to enable the use of a novel biomarker for deep brain stimulation treatments

Unmet Need Neuromodulation therapies are used to treat a wide variety of clinical conditions. For example, an estimated 150,000 deep brain stimulation (DBS) implants are performed globally to help treat movement disorders like Parkinson’s Disease.…

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Methods and compositions for treating protein aggregation diseases

Methods and compositions for treating protein aggregation diseases

Unmet Need Neurodegenerative disease affects more than 50 million people per year. Certain neurodegenerative diseases, like Alzheimer’s disease, result from the accumulation of amyloid-forming proteins in the brain, which results in cognitive impairment and has…

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