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Beta-arrestin inhibition to prevent S1P1 internalization as a treatment for intracranial diseases
Value Proposition Glioblastomas (GBMs) are among the most common and deadly malignant brain tumors with a mean survival time of approximately 14-15 months following diagnosis. Current treatments for GBMs include surgery, radiation, and chemotherapy, however,…
Method of deep brain stimulation for use in treating Parkinson’s Disease
Value Proposition Parkinson’s disease is a common neurodegenerative disorder that progressively deteriorates the motor system. With over seven million people afflicted globally and a rising incidence rate, improved treatment options for Parkinsonian symptoms will be…
Suppression of neuropathic pain by intrathecal delivery of bone marrow stem cells
Value proposition Neuropathic pain is a chronic, often debilitating condition caused by damage or injury to the nerves. Neuropathic pain is a common condition that result from various conditions trauma, viral infections, cancer, neurological conditions…
Magnetic resonance imaging method for detecting magnetic field oscillations
This invention is a new magnetic resonance imaging method that can detect magnetic field oscillations in specific frequency bands, in particular those induced by neuroelectric activity in the brain. In contrast to existing neuroimaging techniques,…
Mouse model of cholinergic dysfunction to evaluate cognitive enhancers for Alzheimer’s disease treatment
Value Proposition Defects in acetylcholine transmission have been associated with several major neurodegenerative disorders including Alzheimer’s disease, dementia, cerebral palsy, Parkinson’s disease, Huntington’s disease and myasthenia gravis. Although cholinergic dysfunction has been implicated in these…
Shank3 knockout mice as a model for autism
The Shank3B- knockout allele has a neo cassette replacing the PDZ domain (exons 13-16) of the Shank3 gene, resulting altered expression of the Shank3b isoform. These mice may be useful for studying behavioral abnormalities associated…
Miniaturized, ultra-high density, multichannel electrode array for long-term, intra-cranial neuronal recordings
Technology A high-density multichannel microwire electrode array is disclosed. The array can comprise a variable number of electrodes. A method of assembling the array is further disclosed. Additionally, a plurality of devices employing the array…
Model-based optimization of spinal cord stimulation parameters
Value Proposition Spinal cord stimulation (SCS) is an FDA approved therapy for treating chronic lower back and limb pain. SCS is based on the gate control theory of pain, where an implanted pulse generator delivers…
Passive pressure sensor
Value proposition Monitoring Intracranial Pressure (ICP) in patients undergoing neurological conditions is critical in tracking progress and recovery. In conditions such as hydrocephalus, a shunt is used to allow extra cerebrospinal fluid to drain. These…
Novel dystonia treatment drugs
Value Proposition Dystonia is a movement disorder characterized by sustained, often painful involuntary postures, causing motor disabilities and a marked decrease in quality of life. Dystonia is the third most common movement disorder behind Parkinson’s…
Conjugated neuroactive steroid compositions and methods of use thereof
The present disclosure provides modified neuroactive steroids. The modified neuroactive steroids may comprise, consist of, or consist essentially of a therapeutic agent and/or a modifying moiety. The modified neuroactive steroid can have modified characteristics as…
A novel target for therapeutic intervention of muscle atrophy
The present invention provides methods and compositions for modulating HDAC4 activity and modulating the activity of proteins downstream of HDAC4 in the muscle transcriptional pathway in a cell by modulating HDAC4 activity. Further provided are…