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An injectable hydrogel scaffold that delivers gene therapies locally
Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…
Treatment for juvenile neuronal ceriod lipofuscinosis
Unmet Need Juvenile neuronal ceroid lipofuscinosis (JNCL), or Batten disease, is one of the most prevalent pediatric neurodegenerative disorders which occurs with a frequency of between 2 and 4 in 100,000 live births. It starts…
Method for treatment of dementia associated with Alzheimer’s disease and other neurodegenerative diseases
Unmet Need There are over 50 million people worldwide with dementia, with about 10 million new cases diagnosed every year. Though approximately 70% of dementia cases are associated with Alzheimer's disease patients, there is no…
Screening method to identify lead compounds to treat hereditary neurological disorders and other diseases associated with MutSβ activity
Unmet Need The human genome is constantly under the threat of DNA damage and replication errors that can result in mutations. A heterodimer of DNA mismatch repair proteins named MutSβ has been linked to a…
An optimization method for spinal cord stimulation electrodes
Unmet Need Spinal cord stimulation is a trusted and proven treatment for patients with chronic pain, and spinal cord stimulator devices are implanted in 34,000 patients a year. Electrical stimulation is delivered via an implanted…
A new method for treating chronic pain including cancer pain
Unmet Need According to the CDC, chronic pain has been linked to numerous physical and mental conditions and contributes to high health care costs and low productivity. Available studies estimate that the prevalence of chronic…
The use of arylcyclopropylamine inhibitors in the treatment of Parkinson’s disease
Value Proposition Treatment options for Parkinson’s disease are currently quite limited, and generally involve dopamine replacement therapy with a variety of dopaminergic agents. Levodopa (L-DOPA), the immediate precursor to dopamine, is currently the gold standard…
A device design intended to reduce sound emissions during transcranial magnetic stimulation (TMS)
Unmet Need Transcranial magnetic stimulation (TMS) allows non-invasive stimulation of neurons in the brain using strong, brief magnetic pulses that induce electrical currents in neurons. TMS is widely used for probing brain function and it…
New selective small molecule inhibitors for the treatment of pain and itch
Unmet Need In the United States, an estimated 50 million adults suffer from chronic pain and around 20 million adults suffer from high-impact chronic pain. Ongoing difficulty in safely treating pain has led to the…
An automated surgical robot for tissue resection
Unmet Need Laser surgery has become a critical procedure in the treatment of many conditions, such as brain cancer, skin cancer, and urinary-tract conditions, among others. In addition, laser surgery has been directed to the…
Novel iron chelators that protect cells from oxidative stress
Unmet Need Metal ions play important roles in the proper functioning of any living organism, but pathologies can develop when metal homeostasis is disturbed. Too much loosely bound iron produces “reactive oxygen species” (ROS) that…
Novel drugs for the treatment of dystonia
Value Proposition Dystonia is a classification of rare and debilitating movement disorders, for which there exists few therapeutic options. Treatments include therapy with botulinum neurotoxin to induce paralysis or deep brain stimulation. Not only are…