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An optimization method for spinal cord stimulation electrodes
Unmet Need Spinal cord stimulation is a trusted and proven treatment for patients with chronic pain, and spinal cord stimulator devices are implanted in 34,000 patients a year. Electrical stimulation is delivered via an implanted…
A new method for treating chronic pain including cancer pain
Unmet Need According to the CDC, chronic pain has been linked to numerous physical and mental conditions and contributes to high health care costs and low productivity. Available studies estimate that the prevalence of chronic…
The use of arylcyclopropylamine inhibitors in the treatment of Parkinson’s disease
Value Proposition Treatment options for Parkinson’s disease are currently quite limited, and generally involve dopamine replacement therapy with a variety of dopaminergic agents. Levodopa (L-DOPA), the immediate precursor to dopamine, is currently the gold standard…
A device design intended to reduce sound emissions during transcranial magnetic stimulation (TMS)
Unmet Need Transcranial magnetic stimulation (TMS) allows non-invasive stimulation of neurons in the brain using strong, brief magnetic pulses that induce electrical currents in neurons. TMS is widely used for probing brain function and it…
New selective small molecule inhibitors for the treatment of pain and itch
Unmet Need In the United States, an estimated 50 million adults suffer from chronic pain and around 20 million adults suffer from high-impact chronic pain. Ongoing difficulty in safely treating pain has led to the…
An automated surgical robot for tissue resection
Unmet Need Laser surgery has become a critical procedure in the treatment of many conditions, such as brain cancer, skin cancer, and urinary-tract conditions, among others. In addition, laser surgery has been directed to the…
Novel iron chelators that protect cells from oxidative stress
Unmet Need Metal ions play important roles in the proper functioning of any living organism, but pathologies can develop when metal homeostasis is disturbed. Too much loosely bound iron produces “reactive oxygen species” (ROS) that…
Novel drugs for the treatment of dystonia
Value Proposition Dystonia is a classification of rare and debilitating movement disorders, for which there exists few therapeutic options. Treatments include therapy with botulinum neurotoxin to induce paralysis or deep brain stimulation. Not only are…
One-Thing-Straight: A mobile application-based technology for improving the posture of individuals with Parkinson’s Disease
Value Proposition Parkinson’s Disease (PD) affects over six hundred thousand Americans, and these individuals often have a forward flexed, or bent posture. However, patients often have the musculoskeletal ability to improve their posture but lack…
Beta-arrestin inhibition to prevent S1P1 internalization as a treatment for intracranial diseases
Value Proposition Glioblastomas (GBMs) are among the most common and deadly malignant brain tumors with a mean survival time of approximately 14-15 months following diagnosis. Current treatments for GBMs include surgery, radiation, and chemotherapy, however,…
Method of deep brain stimulation for use in treating Parkinson’s Disease
Value Proposition Parkinson’s disease is a common neurodegenerative disorder that progressively deteriorates the motor system. With over seven million people afflicted globally and a rising incidence rate, improved treatment options for Parkinsonian symptoms will be…
Suppression of neuropathic pain by intrathecal delivery of bone marrow stem cells
Value proposition Neuropathic pain is a chronic, often debilitating condition caused by damage or injury to the nerves. Neuropathic pain is a common condition that result from various conditions trauma, viral infections, cancer, neurological conditions…