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A method to optimize neural activity blocking therapies
Unmet Need The use of kilohertz frequency (KHF) as neuromodulatory therapies that block unwanted neural activity have been applied to treat chronic pain, phantom limb pain, obesity, and other applications. However, the high energy demands…
Use of rifaximin and bacterial strains for treating probable neurodegenerative disorders like Alzheimer’s Disease
Unmet Need There is an urgent need to develop novel therapies for neurodegenerative diseases and conditions such as Alzheimer's disease (AD). Ten percent of people over age 65 and up to 50% over age 85…
Mouse model of Alzheimer’s disease
Unmet Need Alzheimer’s disease is a neurodegenerative disease marked by loss of cognitive function. There is currently no cure for Alzheimer’s disease. In fact, the limited therapies available only alleviate symptoms for a short time…
Biomaterial therapy for healing brain tissue after ischemic stroke
Unmet Need Ischemic stroke affects 692,000 patients annually in the United States, and can result in paralysis and complications related to cognition and motor function. After a stroke, scarring and atrophy can occur at the…
Flexible needle for targeted delivery of chronic pain treatment
Unmet Need For patients suffering from chronic pain associated with degenerative changes, inflammation, neuropathy or cancer, the ability to carry out daily life and work activities is a challenge. Current treatment methods are limited and…
Adjustable tubular retractor for brain surgery
Unmet Need In 2018 the Journal of Neurosurgery estimated that there were 22.6 million patients globally suffering from neurological disorders, with 13.8 million of them requiring surgery. During intracranial operations concerning aneurysms, tumor extractions, and…
Machine learning model to improve adult ADHD diagnosis
Unmet Need Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with a substantial effect on families and society. It is marked by the person’s hyperactivity, inability to keep focus and control impulsive behaviors. Despite…
Gene therapy and small molecule treatment of chronic pain without addiction
Unmet Need Chronic pain is an escalating issue worldwide – in the U.S., an estimated one of five adults are affected. Chronic pain is difficult to treat, often requiring powerful opioids to provide relief. These…
A method to improve the clinical utility of kilohertz frequency alternating current devices to treat neurological disorders
Unmet Need Many neurological disorders, including pain and spasticity, are characterized by undesirable increases in sensory, motor, or autonomic nerve activity. Local application of kilohertz frequency alternating currents (KHFAC) can effectively and completely block the…
A method of treating neurodegenerative diseases by preventing mitochondrial dysfunction
Unmet Need Alzheimer's Disease (AD) is a devastating neurological disorder that results in significant cognitive impairment and memory loss. A common feature in late onset AD patients is the accumulation of amyloid plaques in the…
Clenbuterol Therapy for Amyotrophic Lateral Sclerosis
Unmet Need Amyotrophic lateral sclerosis (ALS) is a debilitating disease with progressive loss of muscle function and inevitable death usually in 3-5 years. There are currently two available therapies on the market which prolong life…
An injectable hydrogel scaffold that delivers gene therapies locally
Unmet Need Gene therapy has applications ranging from tissue engineering to vaccine development to infectious disease. Most approaches to deliver nucleic material involve the systemic intravenous delivery of condensed nucleic acid (e.g., within a virus…