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Surgical device to insert graft between skull and dura
Unmet Need About 16,000 patients per year are diagnosed with a mastoid space defect. This is a defect in the skull that leads to hearing loss caused by cerebrospinal fluid leaking into the mastoid space,…
Gene therapy for ATP1A3-Related Neurologic Disorders
Unmet Need Children with Alternating Hemiplegia of Childhood can have episodes of temporary paralysis, dystonia, and severe behavioral problems. The prevalence of AHC is estimated to be 1 in one million to 1 out of…
Non-opioid treatment for chronic pain using a neurotensin receptor 1 modulator
Unmet Need For individuals experiencing chronic pain, day-to-day tasks and activities can become difficult or impossible. It can also lead to other long-term health challenges including insomnia, stress, anxiety, and depression. Chronic pain is so…
Engineered conductive polymer for neural activity recording
Unmet Need Dysfunctions in neural circuit activity underlie complex psychiatric diseases such as depression, schizophrenia, Alzheimer’s disease, and others. Neural activity recording is critical to understand brain function and how aberrations in neural circuits lead…
Genetically encoded neuronal electrophysiology
Unmet Need An essential part of studying the brain is understanding how a symphony of neurons activate together, as a circuit, to carry out specific functions. Studying these circuits sheds valuable insight into healthy neurons…
Improved beta oscillation burst detection for assessment of Parkinson’s disease
Unmet Need Parkinson’s disease is a debilitating ailment, though therapies such as deep brain stimulation via electrodes can improve symptoms. Such therapies rely on feedback from biomarkers to adjust the stimulation parameters. Such biomarkers may…
A tool to facilitate high affinity binding between beta-Arrestin and GPCR
Unmet Need Beta-arrestins are a highly conserved family of cytosolic adaptor proteins that contribute to a multitude of physiological functions through a canonical interaction with various G protein-coupled receptors (GPCRs). Through agonist binding to GPCRs,…
Method to optimize spinal cord stimulation therapy placement and parameters
Unmet Need Spinal cord stimulation (SCS) is an FDA approved therapy that stimulates the spinal cord using electrical pulses. This therapy is used to treat chronic pain, and it is estimated 50,000 spinal cord stimulating…
A method to optimize neural activity blocking therapies
Unmet Need The use of kilohertz frequency (KHF) as neuromodulatory therapies that block unwanted neural activity have been applied to treat chronic pain, phantom limb pain, obesity, and other applications. However, the high energy demands…
Use of rifaximin and bacterial strains for treating probable neurodegenerative disorders like Alzheimer’s Disease
Unmet Need There is an urgent need to develop novel therapies for neurodegenerative diseases and conditions such as Alzheimer's disease (AD). Ten percent of people over age 65 and up to 50% over age 85…
Mouse model of Alzheimer’s disease
Unmet Need Alzheimer’s disease is a neurodegenerative disease marked by loss of cognitive function. There is currently no cure for Alzheimer’s disease. In fact, the limited therapies available only alleviate symptoms for a short time…
Biomaterial therapy for healing brain tissue after ischemic stroke
Unmet Need Ischemic stroke affects 692,000 patients annually in the United States, and can result in paralysis and complications related to cognition and motor function. After a stroke, scarring and atrophy can occur at the…