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Aptamer anticoagulant therapy to reduce complications of ECMO treatment
Unmet Need Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment for critically ill patients with low oxygen levels. During ECMO, the patient’s blood flows through an external oxygenation device. This requires co-treatment with an anticoagulant…
Near-infrared fluorescent proteins for live cell and animal imaging
Unmet Need Fluorescent microscopy is one of the most common research tools used by biologists and has a global market value expected to exceed $768 million by 2023. Many of the currently available fluorescent protein…
Aptamers to Glycoprotein VI
Value Proposition Millions of Americans have received antiplatelet agents to prevent pathological blood clot formation (thrombosis). Platelets are the key prothrombotic element, forming aggregates that lead to blood clots. Antiplatelet therapies can counteract this process.…
Controlling coagulation with aptamer combinations and aptamer-drug combinations and their antidotes
Value Proposition Millions of Americans have received anticoagulative agents to prevent pathological blood clot formation (thrombosis). For decades, warfarin and heparin have been the centerpiece of anticoagulative treatment. In the past decade, new anticoagulative agents…
RNA Aptamers Targeting a coagulation Cascade Cofactor
Value Proposition Thrombosis (blood clots within blood vessels) is a major underlying factor in many cardiovascular diseases and a major source for complications following hospital stays and surgeries. Venous thrombosis occurs in approximately 1 per…
RNA aptamers for thrombi imaging
Value Proposition Thrombosis (blood clots within blood vessels) is a major underlying factor in many cardiovascular diseases and a major source for complications following hospital stays and surgeries. Venous thrombosis occurs in approximately 1 per…