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SUMOylation as a therapeutic target in inflammatory bowel diseases and sepsis
Unmet Need Inflammatory Bowel Disease (IBD) affects between 2.4 – 3.1 million people in the USA alone, with significant risks of complications such as sepsis. Chronic inflammation from IBD results in severe intestinal tissue damage,…
Novel factor VIIa chimeras for safer hemostasis
Unmet Need Chronic wounds impact 6.5 million patients in the US, leading to complications such as infections, hemorrhage, gangrene, and amputations. The resulting health burden costs the US healthcare system an estimated $25 billion annually…
A method of determining resistance of a blood cancer to PI3K inhibitors as well as treating blood cancers
Unmet Need Lymphomas are highly diverse and among the most common cancers in the US; approximately 1 in 50 Americans will be diagnosed with a lymphoma in their lifetime. Standard therapy for lymphomas generally includes…
G protein-coupled receptor kinase 2 and beta arrestins as therapeutic targets and diagnostic tools for hemoglobinopathies
Value Proposition Sickle cell disease affects millions of people throughout the world. Patients with sickle cell disease often experience episodes of acute pain that are caused by vaso-occlusive crisis. It is the leading cause of…
Aptamers to VMF
Focused aptamer libraries are constructed in accordance with a proteome (i.e., complex mixture of native biomolecules). The libraries may be screened to identify one or more candidate aptamers with desired biological activities other than specific…