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New small molecules targeting castration-resistant prostate cancer

New small molecules targeting castration-resistant prostate cancer

Unmet Need Prostate cancer (PC) is the second most common male cancer globally and represents 15% of all cancers diagnosed in males. An estimated 34,700 deaths were predicted to occur from PC in the U.S.…

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Gene expression assay to determine radiation exposure

Gene expression assay to determine radiation exposure

Unmet Need Ionizing radiation poses a significant risk as an environmental hazard and is linked to the development of multiple cancers in adults and children. Healthcare professionals, nuclear power plant employees, and research scientists are…

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Structural variants of TERT in brain tumors

Structural variants of TERT in brain tumors

Unmet Need Glioblastoma is the most common type of malignant brain tumor, and accounts for 47.7% of all brain cancer cases. Despite aggressive treatment, the median overall survival for glioblastoma is 15 to 18 months.…

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A simple blood test that can predict heart failure earlier than current methods

A simple blood test that can predict heart failure earlier than current methods

Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…

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Breast cancer risk prediction technology using genomic classifier

Breast cancer risk prediction technology using genomic classifier

Unmet Need The earliest form of breast cancer, ductal carcinoma in situ (DCIS), is diagnosed in almost 50,000 people in the U.S. each year. DCIS is considered noninvasive, as abnormal cells have not spread out…

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A genomics-based method to identify cancer patients that will benefit from immune checkpoint therapy

A genomics-based method to identify cancer patients that will benefit from immune checkpoint therapy

Unmet Need Non-small-cell lung cancer accounts for 82% of all lung cancer diagnoses. Immune checkpoint blockade treatment is an exciting new course of action among advanced stage non-small-cell lung cancer patients. However, only a minority…

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Genomic Biomarkers of Locally Advanced Breast Cancer (LABC) and Inflammatory Breast Cancer (IBC)

Genomic Biomarkers of Locally Advanced Breast Cancer (LABC) and Inflammatory Breast Cancer (IBC)

Unmet Need Locally advanced breast cancer (LABC) and inflammatory breast cancer (IBC) are associated with high 5-year mortality rates (respectively 55% and 33%), especially when compared to early-stage breast cancers (~80%). LABC and IBC are…

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Detecting and predicting progression of osteoarthritis by biomarker analysis

Detecting and predicting progression of osteoarthritis by biomarker analysis

Unmet Need Osteoarthritis (OA) is a prevalent chronic disease that impacts 32.5 million US adults and hundreds of millions worldwide. Further, global incidence of OA is increasing due to rises in geriatric populations and other…

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Surface acoustic wave based separation techniques

Surface acoustic wave based separation techniques

Value Proposition Complex biofluids such as blood, urine etc. contain a plethora of particles of interest that are of diagnostic and research interest. Examples of such particles may include exosomes, or Circulating Tumor Cells (CTC).…

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HIV-1 incidence biomarkers

HIV-1 incidence biomarkers

Background Measures of HIV incidence are used to help public health officials, researchers, and policy makers monitor the epidemic, evaluate the impact of interventions, and assist in the identification of sites for HIV prevention trials.…

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Wearable device for early detection of influenza and common cold

Wearable device for early detection of influenza and common cold

Unmet Need Approximately 10% of the US population is infected with influenza each year resulting in 3 to 5 million severe cases and up to 500,000 deaths. Early detection of influenza-like illness can limit the…

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A method of identifying a B cell malignancy as Hodgkin’s Lymphoma

A method of identifying a B cell malignancy as Hodgkin’s Lymphoma

Unmet Need Malignancies derived from mature B cells are common and constitute the majority of blood cancers. The biology of these leukemias and lymphomas reflect defined stages of normal B-cell differentiation. Correct diagnosis of B…

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