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A simple blood test that can predict heart failure earlier than current methods

A simple blood test that can predict heart failure earlier than current methods

Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…

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A simple metabolomic profile to predict risk of subsequent cardiovascular events

A simple metabolomic profile to predict risk of subsequent cardiovascular events

Value Proposition Coronary artery disease (CAD) is the leading cause of death in industrialized countries, and in concert with the epidemic of obesity and diabetes, is rapidly becoming the leading cause of death in developing…

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Gene polymorphisms to identify altered effectiveness of beta blocker therapy in cardiac surgery candidates

Gene polymorphisms to identify altered effectiveness of beta blocker therapy in cardiac surgery candidates

Unmet Need Postoperative atrial fibrillation (AF) is the most common complication following the coronary artery bypass graft surgery (CABG), occurring in 20% to 40% of patients. Studies indicate that postoperative AF is associated with an…

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Genomic predictors of mortality following heart surgery

Genomic predictors of mortality following heart surgery

Unmet Need Several models have been developed to estimate the risk of mortality following cardiac surgery, including the European System for Cardiac Operative Risk Evaluation (EuroSCORE), but they all are limited in their ability to…

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Metabolite biomarkers of human heart failure

Metabolite biomarkers of human heart failure

Value Proposition Heart failure is a very common condition affecting approximately 5.1 million people in the United States. Due to its association with age, the incidence of heart failure, as well as the cost of…

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Mast cell targeting to predict and prevent virus-induced vascular leakage

Mast cell targeting to predict and prevent virus-induced vascular leakage

Value Proposition Dengue is a mosquito spread virus that affects millions of people worldwide. According to the World Health Organization, there are approximately 390 million dengue virus infections each year, and it is the leading…

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Biomarkers to measure patient platelet functional status on aspirin and predict cardiovascular events

Biomarkers to measure patient platelet functional status on aspirin and predict cardiovascular events

Value Proposition Aspirin is the most commonly prescribed anti-platelet medication for prevention of acute coronary syndrome (ACS), which continues to be the leading cause of morbidity and mortality in the U.S. Aspirin has long been…

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