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Gene polymorphisms to identify altered effectiveness of beta blocker therapy in cardiac surgery candidates
Unmet Need Postoperative atrial fibrillation (AF) is the most common complication following the coronary artery bypass graft surgery (CABG), occurring in 20% to 40% of patients. Studies indicate that postoperative AF is associated with an…
Metabolite biomarkers of human heart failure
Value Proposition Heart failure is a very common condition affecting approximately 5.1 million people in the United States. Due to its association with age, the incidence of heart failure, as well as the cost of…
Prognostic and predictive blood-based biomarkers for pancreatic cancer
Value Proposition Pancreatic cancer is among the deadliest types of cancer, with only 8.2% of patients surviving five years after diagnosis. Therapeutics that inhibit either VEGF signaling pathways or mitogenic signaling through the epidermal growth…
Components of the Wnt-Beta-catenin paracrine signaling pathway as predictive biomarkers for cancer immunotherapy
Value Proposition Immunotherapy is a promising approach for the treatment of many cancers. However, despite early success, majority of patients with advanced cancer fail to respond or become resistant. In even the most immunogenic cancer…
A diagnostic test for differentiating follicular thyroid adenoma for follicular thyroid carcinoma
Duke University is seeking a company interested in commercializing a novel method to distinguish follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC). Global estimates of thyroid cancer incidence for 2006 indicate half a million…
Mast cell targeting to predict and prevent virus-induced vascular leakage
Value Proposition Dengue is a mosquito spread virus that affects millions of people worldwide. According to the World Health Organization, there are approximately 390 million dengue virus infections each year, and it is the leading…
Enhancing of homing and/or engraftment of cord blood mononuclear cells in the central nervous system
Value Proposition Leukodystrophies are inherited disorders resulting in decreased motor function, muscle rigidity, degeneration of sight and hearing, and are ultimately fatal. There is a great lack of treatment, although cord blood mononuclear (CBM) and…
Biomarkers to measure patient platelet functional status on aspirin and predict cardiovascular events
Value Proposition Aspirin is the most commonly prescribed anti-platelet medication for prevention of acute coronary syndrome (ACS), which continues to be the leading cause of morbidity and mortality in the U.S. Aspirin has long been…
Blood-based biomarkers for colon cancer
Value Proposition Of cancers that affect both men and women, colorectal cancer is the second leading cancer killer in the United States. Agents that inhibit either VEGF signaling pathways or mitogenic signaling through the epidermal…