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A method of identifying a B cell malignancy as Hodgkin’s Lymphoma
Unmet Need Malignancies derived from mature B cells are common and constitute the majority of blood cancers. The biology of these leukemias and lymphomas reflect defined stages of normal B-cell differentiation. Correct diagnosis of B…
A method of screening and monitoring glycogen storage diseases with a single biomarker
Unmet Need Glycogen storage disease type I (GSD I) is an autosomal recessive inherited disorder of carbohydrate metabolism associated with life threatening fasting hypoglycemia, and significant morbidity and mortality. Currently, the standard of care therapy…
Predicting immune checkpoint therapy for breast cancer patients using LRRK2 mutations
Unmet Need The treatment of various cancers has been revolutionized by the development of effective immunotherapies that are now established as powerful clinical tools. Unfortunately, it is also now well documented that only a minority…
A method of determining resistance of a blood cancer to PI3K inhibitors as well as treating blood cancers
Unmet Need Lymphomas are highly diverse and among the most common cancers in the US; approximately 1 in 50 Americans will be diagnosed with a lymphoma in their lifetime. Standard therapy for lymphomas generally includes…
A method for identifying sour-taste receptor ligands as well as compounds that modulate their activity
Unmet Need The taste system is essential for feeding and survival as it helps humans evaluate the nutritional content in food. Every year, taste and smell dysfunctions affect more than 200,000 people, including those undergoing…
Biomarkers for high-grade serous ovarian carcinomas
Unmet Need The Amercian Cancer Society estimates that over 20,000 women in the United States will be diagnosed with and over 13,000 women will die from ovarian cancer this year. High-grade serous ovarian carcinoma (HGSC)…
A target for identifying and treating metabolic diseases including insulin resistance
Unmet Need The World Health Organization attributes over 70% of all deaths globally to noncommunicable diseases (NCD) including cardiovascular disease, diabetes, and cancer. Risk factors for NCDs include obesity, raised blood pressure, and the regional…
A therapeutic target to prevent or treat castration-resistant prostate cancer
Unmet Need Prostate cancer is the second leading cause of cancer death in American men. Androgen deprivation therapy has been the standard of care for initial management of advanced prostate cancer, but resistance to therapy…
A simple metabolomic profile to predict risk of subsequent cardiovascular events
Value Proposition Coronary artery disease (CAD) is the leading cause of death in industrialized countries, and in concert with the epidemic of obesity and diabetes, is rapidly becoming the leading cause of death in developing…
Gene signature for prediction of acute rejection in kidney transplant
Unmet Need Kidney transplant is the best current treatment for kidney failure. The kidney is the most common organ to be transplanted, and in 2019 there were 23,405 kidney transplants in the United States. Unfortunately,…
Molecular diagnostic test for acute respiratory viral infections
Unmet Need Acute respiratory viral (ARV) infections are among the most common reasons for patient visits in primary and acute care settings. ARV can be caused by many viruses including human rhinovirus (HRV), respiratory syncytial…
Gene polymorphisms to identify altered effectiveness of beta blocker therapy in cardiac surgery candidates
Unmet Need Postoperative atrial fibrillation (AF) is the most common complication following the coronary artery bypass graft surgery (CABG), occurring in 20% to 40% of patients. Studies indicate that postoperative AF is associated with an…