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Methods and formulation to improve cellular survival of thawing after cryopreservation
Unmet Need Cryopreservation is the main method of long-term storage and transport of living cells, and it is used for cell lines and patient samples such as stem cells, CAR-T cells, bone marrow, cord blood,…
A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate
Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…
Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity
Value Proposition Since insulin was used as the first therapeutic protein in a clinical setting, the field of protein therapeutics has rapidly expanded. From 2014-2018, therapeutic proteins had the highest compound annual growth rate of…
Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions
Value Proposition Proteins can be useful therapeutic agents when engineered for specificity and selectivity for a clinical target. Their complexity, versatility, tolerability, and diversity often make them superior alternatives to small molecule drugs, and the…
An integrated hybrid biological-materials platform for portable production of biomacromolecules
Value Proposition Bacteria are a common host to produce diverse biologics, accounting for ~30% of biopharmaceuticals. The industrial synthesis of recombinant proteins using bacterial hosts entails multiple steps that each require a sophisticated and delicate…