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Anti-cancer therapeutic for the induction of apoptosis in solid tumors via TRAIL receptors
Unmet Need Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL, CD253) acts as an activator of apoptosis in many tumor cells, while remaining innocuous to normal cells. Both membrane-bound and soluble forms of TRAIL can trigger apoptosis…
Enzymatic synthesis of aptamer-targeted polynucleotide drug delivery platforms for cancer therapy
Unmet Need In the United States alone, over 1.8 million new patients were diagnosed with cancer in 2021, and over 600,000 patients died from the disease. Cytostatic nucleotides, such as gemcitabine and 5-fluorouracil, have been…
A stable, easily manufactured intranasal oxytocin formulation that contains only food grade preservatives
Unmet Need Current formulations of oxytocin used for the treatment of neuropsychiatric disorders have several drawbacks. For example, many intravenous and intranasal formulations, like those approved in Europe, contain preservatives like chlorobutanol which is highly…
A class of biodegradable stealth polymers to improve drug delivery
Unmet Need Delivery of drugs or therapeutics such as small molecules, peptides, and proteins, in their native form, is limited by their poor stability, low solubility, and short in vivo circulation. These challenges in drug…
Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity
Value Proposition Since insulin was used as the first therapeutic protein in a clinical setting, the field of protein therapeutics has rapidly expanded. From 2014-2018, therapeutic proteins had the highest compound annual growth rate of…
Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions
Value Proposition Proteins can be useful therapeutic agents when engineered for specificity and selectivity for a clinical target. Their complexity, versatility, tolerability, and diversity often make them superior alternatives to small molecule drugs, and the…