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HIV treatment and prevention using broadly neutralizing antibodies

HIV treatment and prevention using broadly neutralizing antibodies

Unmet Need For over 40 years, the human immunodeficiency virus (HIV) pandemic has affected the quality of life and decreased the life expectancy for millions of people with approximately 1.5 million new cases each year.…

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Dual agonist proteins for the treatment of type 2 diabetes

Dual agonist proteins for the treatment of type 2 diabetes

Unmet Need Over 37 million people in the United States have diabetes, and approximately 90-95% of them have type 2 diabetes (T2D). Diabetes and its related complications not only cause premature mortality and lower quality…

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Anti-cancer therapeutic for the induction of apoptosis in solid tumors via TRAIL receptors

Anti-cancer therapeutic for the induction of apoptosis in solid tumors via TRAIL receptors

Unmet Need Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL, CD253) acts as an activator of apoptosis in many tumor cells, while remaining innocuous to normal cells. Both membrane-bound and soluble forms of TRAIL can trigger apoptosis…

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Biomaterial therapy for healing brain tissue after ischemic stroke

Biomaterial therapy for healing brain tissue after ischemic stroke

Unmet Need Ischemic stroke affects 692,000 patients annually in the United States, and can result in paralysis and complications related to cognition and motor function. After a stroke, scarring and atrophy can occur at the…

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Aptamer anticoagulant therapy to reduce complications of ECMO treatment

Aptamer anticoagulant therapy to reduce complications of ECMO treatment

Unmet Need Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment for critically ill patients with low oxygen levels. During ECMO, the patient’s blood flows through an external oxygenation device. This requires co-treatment with an anticoagulant…

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Enzymatic synthesis of aptamer-targeted polynucleotide drug delivery platforms for cancer therapy

Enzymatic synthesis of aptamer-targeted polynucleotide drug delivery platforms for cancer therapy

Unmet Need In the United States alone, over 1.8 million new patients were diagnosed with cancer in 2021, and over 600,000 patients died from the disease. Cytostatic nucleotides, such as gemcitabine and 5-fluorouracil, have been…

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A stable, easily manufactured intranasal oxytocin formulation that contains only food grade preservatives

A stable, easily manufactured intranasal oxytocin formulation that contains only food grade preservatives

Unmet Need Current formulations of oxytocin used for the treatment of neuropsychiatric disorders have several drawbacks. For example, many intravenous and intranasal formulations, like those approved in Europe, contain preservatives like chlorobutanol which is highly…

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A class of biodegradable stealth polymers to improve drug delivery

A class of biodegradable stealth polymers to improve drug delivery

Unmet Need Delivery of drugs or therapeutics such as small molecules, peptides, and proteins, in their native form, is limited by their poor stability, low solubility, and short in vivo circulation. These challenges in drug…

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A method for treating TRAIL-resistant cancers

A method for treating TRAIL-resistant cancers

Unmet Need Over the past twenty years, TNF-related apoptosis-inducing ligand (TRAIL) has been shown to kill a variety of human cancer cells in vitro and in vivo while remaining innocuous to healthy cells. Unfortunately, the…

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A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate

A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate

Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…

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A fully human EGFRvIII-targeted bispecific antibody engaging T cells for antitumor therapy

A fully human EGFRvIII-targeted bispecific antibody engaging T cells for antitumor therapy

Value Proposition The most common malignant brain tumor, glioblastoma multiforme (GBM), remains uniformly fatal despite surgery, radiation, and chemotherapy. Conventional therapy for malignant glioma fails to specifically target tumor cells. In contrast, substantial evidence indicates…

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Sublingual immunization using supramolecular peptide-polymer conjugate tablets

Sublingual immunization using supramolecular peptide-polymer conjugate tablets

Value proposition Immunization with vaccines prevent illness, disability, and currently avert an estimated 2 to 3 million deaths every year. However, commonly-used vaccine technology platforms can be unpredictable, require a high manufacturing cost, and often…

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