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LpxH targeting antibiotics for Gram-negative bacteria

LpxH targeting antibiotics for Gram-negative bacteria

Unmet Need Antimicrobial resistance of bacteria to antibiotics is a major threat to public health. In 2019, 4.95 million deaths, 64% of all bacterial infection related deaths globally, were attributed to antimicrobial resistance to antibiotics.…

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A process to access selectively 1,4-diamines with two stereogenic centers that can aid in identifying new drug compounds

A process to access selectively 1,4-diamines with two stereogenic centers that can aid in identifying new drug compounds

Unmet Need When developing new drugs, researchers often rely on naturally occurring compounds to learn what design features illicit a biological response that can be tailored for treating a given disease or ailment. However, reproducing…

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Intravesical UTI vaccine to induce bacteria-eradicating immune responses in the bladder

Intravesical UTI vaccine to induce bacteria-eradicating immune responses in the bladder

Unmet Need Urinary tract infections (UTI) are typically caused by uropathogenic E. coli (UPEC) that proliferate in urine and infect the urethra and bladder epithelial cells. UTIs represent the second most common bacterial infection in…

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CRISPR-based antiviral treatment of coronavirus infections

CRISPR-based antiviral treatment of coronavirus infections

Unmet Need The global market for antiviral drugs is a large one, topping $60B, and is getting larger due to the ongoing COVID-19 pandemic. Spurred on by a $3B investment from the U.S. government into…

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A therapeutic vaccine platform for treating influenza viruses

A therapeutic vaccine platform for treating influenza viruses

Value Proposition Influenza virus infections represent a substantial global burden on human health. Each year, it is estimated that influenza viruses cause up to 5 million severe infections globally, resulting in up to 645,000 mortalities.…

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Prochelators as targeted prodrugs for prostate cancer

Prochelators as targeted prodrugs for prostate cancer

Value Proposition Globally, prostate cancer is the second-leading cause of new cancer cases in men and the sixth-leading cause of cancer-related death in men. Prostate-related health issues are on the rise, and the number of…

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Antimicrobial prochelators to target drug-resistant bacteria

Antimicrobial prochelators to target drug-resistant bacteria

Value Proposition According to the CDC, each year 2.8 million people in the United States develop an antibiotic-resistant infection, leading to more than 35,000 deaths. Beta lactams were the largest segment in the antibiotics market…

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Replication competent bi- and tri-valent influenza viruses as vaccines

Replication competent bi- and tri-valent influenza viruses as vaccines

Value Proposition Influenza infection is a major public health concern, with an estimated 200,000 Americans hospitalized each year with flu or flu-related illness. The most effective method for flu prevention is vaccination, however, due to…

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Compositions and methods for treating gram-negative bacterial infection

Compositions and methods for treating gram-negative bacterial infection

Value Proposition Antimicrobial resistance is considered to be one of the biggest crises facing modern medicine today. Without desperately needed intervention, it is estimated that by 2050 over 10 million deaths per year will be…

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