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Advanced adaptive cooling fabric
Unmet Need With the rise of temperatures due to global warming, the risk of heat-related illnesses such as heat exhaustion and heatstroke is on the rise as well. Some of the most vulnerable are those…
Novel TRPV4-Targeted Therapy for Arrhythmic Cardiomyopathy
Unmet Need Arrhythmic cardiomyopathy (ACM) is a life-threatening condition characterized by fatty-fibrotic remodeling of the heart muscle, leading to arrhythmias, heart failure, and sudden cardiac death. While 60% of ACM cases are linked to known…
Targeted Ablation and Replacement of Sertoli Cells for Infertility Treatment
Value Proposition Infertility affects 10-15% of couples, with up to 50% of cases attributed to male factors. While 30% of male infertility cases are idiopathic, around 5-10% of cases are believed to be linked to…
Computer Aided Detection Tool for Difficult-to-Detect Brain Metastases
Unmet Need An estimated 20% of all cancer patients will develop brain metastases in their lifetime. These metastases are first diagnosed by neuroradiologists using CT, and more commonly, MR imaging. If a limited number of…
Novel ligand to target KRas-related cancers
Unmet Need Cancer is a serious health issue characterized by the abnormal growth of cells that invade and destroy healthy tissue. Nearly one in five human cancers features KRAS mutations, making it one of the…
A method to increase the durability and lifespan of commercially available soft polymer networks
Unmet Need Soft polymers are used for a variety of products including biomedical implants, footwear, and tires. Having a more durable polymer product will increase not only the lifespan of the product but also the…
Novel epigenetic therapy for Prader Willi Syndrome
Unmet Need Prader-Willi Syndrome (PWS) is a rare and complex genetic disorder affecting an estimated 1 in 10,000 to 30,000 infants. Primarily caused by a paternal chromosome 15q11-q13 deletion, PWS presents a myriad of physical,…
Probiotic-based prevention of respiratory infections
Unmet Need Pneumonia is the leading infectious killer of children, causing over 800,000 deaths annually. Streptococcus pneumoniae remains a major driver of these fatalities, even with widespread vaccination. Current vaccines are insufficient to address all…
Small molecules that can safely exploit copper as an antimicrobial
Value Proposition The fungal pathogen Cryptococcus neoformans can live in both plants and animals, but when inhaled by humans can disseminate from the lungs to the bloodstream and cause life-threatening systemic disease. The brain is…
Gene therapy for ATP1A3-Related Neurologic Disorders
Unmet Need Alternating Hemiplegia of Childhood (AHC) is a rare neurologic disorder affecting children, causing episodes of temporary paralysis, dystonia, and severe behavioral issues, with prevalence estimates ranging from 1 in 1 million to 1…
Temporally Dependent Iterative Expansion (TEDIE), a novel algorithm that accurately identifies seizure-causing epileptic zones in the brain
Unmet Need Epilepsy is one of the most common neurological conditions, affecting approximately 50 million people worldwide as of 2023. Patients with epilepsy face a risk of premature death up to three times higher than…
Personalized Behavioral Risk Prediction Technology
Unmet Need Daily environments significantly influence mental and physical health, impacting factors like stress, sleep quality, and behaviors tied to addiction and mental health conditions. For example, specific environments may trigger smoking, exacerbate insomnia, or…