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Showing 18 matches for the following: Inventor: "Chilkoti, Ashutosh" ×
Thermally-responsive elastin-like peptides for improving the efficacy of anticancer agents
Unmet Need The goal of chemotherapy is to deliver an anticancer agent, typically a small molecule, at a high dose to a tumor to kill rapidly proliferating tumor cells. Unfortunately, the maximum dose of many…
Genetically encoded hybrid biomaterials that are thermally responsive and tunable
Unmet Need Developing new biomaterials is an active area of research, with applications in tissue engineering, regenerative medicine, and drug-delivery. In particular, protein- and peptide-based materials are attractive candidates for these applications because of their…
Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity
Value Proposition Since insulin was used as the first therapeutic protein in a clinical setting, the field of protein therapeutics has rapidly expanded. From 2014-2018, therapeutic proteins had the highest compound annual growth rate of…
Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions
Value Proposition Proteins can be useful therapeutic agents when engineered for specificity and selectivity for a clinical target. Their complexity, versatility, tolerability, and diversity often make them superior alternatives to small molecule drugs, and the…
Antibodies for the detection of Ebola virus infection
Value Proposition Ebola Virus Disease (EVD) is a severe, often fatal illness in humans caused by one of five different Ebola viruses. The virus is transmitted to people from wild animals and spreads in the…
Printed biosensors from carbon nanotube thin-film transistors and non-fouling polymer interface layer for label-free, electronic sensing of disease markers in whole blood
Value Proposition The future of diagnostics is in rapid point-of-care detection. The proposed technology is a single-step biosensor that allows for quicker and simpler disease-associated analyte detection. Technology We have developed printed biosensor capable of…