- Agriculture
- Antibiotic/anti-viral
- Biologics
- Biomarkers
-
By Clinical Application
- Anesthesiology
- Blood & Lymphatic Disease
- CNS & Neurosciences
- Dermatology
- Diabetes, Metabolism, Endocrinology & Obesity
- Ear, Nose, & Throat
- Emergency Services
- Gastroenterology & Digestive Disease
- General & Plastic Surgery
- Health Education, Medical Training and Operations
- Heart and Vascular
- Immunology, Autoimmune & Inflammation
- Infectious Diseases
- Mental Health
- Multiple clinical applications
- Musculoskeletal Disorders, Orthopedics/Bone
- Nephrology/Renal
- Oncology
- Ophthalmology
- Orphan Diseases
- Pediatrics
- Physical Medicine & Rehabilitation
- Radiology
- Regenerative Medicine / Tissue Engineering
- Reproductive Health: Obstetrics & Gynecology
- Respiratory & Pulmonary
- Surgery
- Transplantation
- Urology
- Wound Healing
- COVID-19
- Creative Works
- Diagnostics
- Drug Delivery
- Drug screening and discovery
- Energy, Cleantech & Environmental
- Engineering & Physical Sciences
- Gene therapy
- Imaging
- Materials
- Medical Devices
- Nutraceuticals
- Other
- Research & Design Tools
- RNAi/siRNA
- Sensors & Controls
- Small molecules
- Software & Information Technology
- Stem Cells
- Vaccines
- Veterinary Medicine
Showing 20 matches for the following: Inventor: "Caron, Marc G" ×
The use of arylcyclopropylamine inhibitors in the treatment of Parkinson’s disease
Value Proposition Treatment options for Parkinson’s disease are currently quite limited, and generally involve dopamine replacement therapy with a variety of dopaminergic agents. Levodopa (L-DOPA), the immediate precursor to dopamine, is currently the gold standard…
Sequence of the gene and protein encoding the human D1 dopamine receptor
Value Proposition The Dopamine D1 receptor is known to regulate neuronal growth and development, in addition to playing important roles in learning and memory, locomotion, and other essential neural activities. Further investigation into its function…
A cDNA clone encoding a functional L-proline transporter expressed in rat brain
Value Proposition The L-proline transporter is expressed in several subpopulations of glutamatergic neurons and is implicated in higher cortical functions and memory. Several CNS disorders are associated with L-proline transporter abnormalities, and thus tools for…
An expressible antidepressant-sensitive serotonin transporter
Value Proposition Serotonin-targeting antidepressants are now prescribed for a wide spectrum of disorders, including obsessive-compulsive disorder, depression, as well as eating, sleep, and panic disorders. Next generation therapeutic strategies to combat these disorders, and to…
Mouse model of cholinergic dysfunction to evaluate cognitive enhancers for Alzheimer’s disease treatment
Value Proposition Defects in acetylcholine transmission have been associated with several major neurodegenerative disorders including Alzheimer’s disease, dementia, cerebral palsy, Parkinson’s disease, Huntington’s disease and myasthenia gravis. Although cholinergic dysfunction has been implicated in these…
Dopamine transporter knockout mouse
We have developed knockout mice lacking the dopamine transporter. These mice are hyperactive, and display cognitive abnormalities consistent with enhanced dopaminergic neurotransmission. They have a heightened dopaminergic state (increase dopamine activity), mimicking certain behaviors associated…
Mice carrying functional single nucleotide polymorphisms in brain-specific trytophan hydroxylase(Tph2)
We have developed mice expressing 2 different mutant alleles of the brain-specific tryptophan hydroxylase gene (Tph2). Tryptophan hydroxylase is the rate limiting enzyme involved in the synthesis of serotonin. These mice have significantly reduced levels…
Norepinephrine transporter Knockout Mice
Duke University is seeking a company interested in commercializing a novel and versatile animal model of anti-depressant-related patients. Depression is the fourth leading contributor of disease worldwide with 18.8 million adult sufferers in the United…