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Showing 6 matches for the following: Inventor: "Yan, Hai" ×
Rapid detection of diagnostic TERT promoter mutations in glioblastoma and other cancers
Unmet Need Malignant gliomas are the most common primary central nervous system (CNS) malignancy in adults and are graded I to IV indicating their degree of malignancy. Diffuse gliomas (grade II-IV) account for 80% of…
Rapid detection of diagnostic TERT promoter mutations in glioblastoma and other cancers
Unmet Need Malignant gliomas are the most common primary central nervous system (CNS) malignancy in adults and are graded I to IV indicating their degree of malignancy. Diffuse gliomas (grade II-IV) account for 80% of…
A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate
Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…
Isogenic HCT116 cell lines with heterozygous or homozygous IDH1R132H mutation
Value Proposition One of the major challenges in studying the implications of the IDH1 mutations has been the dearth of cell line models which recapitulate IDH mutation-dependent tumor progression. Technology Researchers at Duke have generated…
Isogenic HCT1116 cell lines with heterozygous or homozygous MLL2 inactivating mutation
HCT 116- MLL2 +/- line (MLL2 heterozygous knockout; two clones)- Deviced from the fibroblast- looking HCT116 line, a human colorectal cancer line which has wild-type MLL2 alleles. Genetic engineering was used to insert a DNA…
Composition and methods of multi-targeted siRNA cocktail for treatment of Glioblastoma Multiforme
Value Proposition Glioblastoma is the most common primary malignant brain tumor in adults, and the prognosis of this disease is dismal, despite aggressive standard-of-care therapy with chemoradiation and gross tumor resection. Several molecular mechanisms are…