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Showing 2 matches for the following: Inventor: "Sotnikova, Tatiana" ×
The use of arylcyclopropylamine inhibitors in the treatment of Parkinson’s disease
Value Proposition Treatment options for Parkinson’s disease are currently quite limited, and generally involve dopamine replacement therapy with a variety of dopaminergic agents. Levodopa (L-DOPA), the immediate precursor to dopamine, is currently the gold standard…
Mice carrying functional single nucleotide polymorphisms in brain-specific trytophan hydroxylase(Tph2)
We have developed mice expressing 2 different mutant alleles of the brain-specific tryptophan hydroxylase gene (Tph2). Tryptophan hydroxylase is the rate limiting enzyme involved in the synthesis of serotonin. These mice have significantly reduced levels…