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Showing 3 matches for the following: Inventor: "Sotnikova, Tatiana" ×

Methods for identifying compounds that regulate beta-arrestin signaling complexes for use as antipsychotic drugs

Methods for identifying compounds that regulate beta-arrestin signaling complexes for use as antipsychotic drugs

Unmet Need About 35% of all drugs approved by the U.S. Food and Drug Administration target G protein-coupled receptors (GPCRs), a large and ubiquitous family of cell surface receptors with important contributions to neurological, hormonal,…

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The use of arylcyclopropylamine inhibitors in the treatment of Parkinson’s disease

The use of arylcyclopropylamine inhibitors in the treatment of Parkinson’s disease

Value Proposition Treatment options for Parkinson’s disease are currently quite limited, and generally involve dopamine replacement therapy with a variety of dopaminergic agents. Levodopa (L-DOPA), the immediate precursor to dopamine, is currently the gold standard…

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Mice carrying functional single nucleotide polymorphisms in brain-specific trytophan hydroxylase(Tph2)

Mice carrying functional single nucleotide polymorphisms in brain-specific trytophan hydroxylase(Tph2)

We have developed mice expressing 2 different mutant alleles of the brain-specific tryptophan hydroxylase gene (Tph2). Tryptophan hydroxylase is the rate limiting enzyme involved in the synthesis of serotonin. These mice have significantly reduced levels…

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