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Showing 3 matches for the following: Inventor: "Sampson, John" ×
A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate
Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…
A fully human EGFRvIII-targeted bispecific antibody engaging T cells for antitumor therapy
Value Proposition The most common malignant brain tumor, glioblastoma multiforme (GBM), remains uniformly fatal despite surgery, radiation, and chemotherapy. Conventional therapy for malignant glioma fails to specifically target tumor cells. In contrast, substantial evidence indicates…
Rapid immunoassay to detect anti-EGFRviii levels to evaluate vaccine efficacy
Value Proposition Tumor-specific molecules offer the possibility of targeted cancer therapy using monoclonal antibodies (mAbs) specifically directed against the tumor-specific molecule. However, it has proven difficult to identify tumor-specific molecules. Overexpression of EGFR in human…