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Showing 11 matches for the following: Inventor: "Lefkowitz, Robert" ×

Plasmids for the overexpression of GPCRs

Plasmids for the overexpression of GPCRs

Technology Duke inventors have generated four novel GPCR plasmids that can be used for the stable overexpression of several GPCRs: pcDNA3-Flag-β2AR pcDNA3-hAT1R (human) pcDNA3-HA-rATlaR (rat) pcDNA3-Flag-rATlaR (rat)

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Cell lines for the overexpression of GPCRs

Cell lines for the overexpression of GPCRs

Technology Duke inventors have generated five novel cell lines that can be used for the stable overexpression of several GPCRs: HEK293-rATlaR (2pM/mg) HEK293-rATlaR (600fM/mg) NIH-3T3-Flag-Smo 1.1 NIH-3T3-Flag-Smo 1.7 HEK293-Flag-β2AR (2pM/mg, W9)

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B-arrestin 1 and 2 conditional knockout mouse models

B-arrestin 1 and 2 conditional knockout mouse models

Technology Duke inventors have created two novel mouse lines for the acute ablation of β-arrestin 1 or β-arrestin 2: Conditional Flox/Cre (tet inducible) β-arrestin 1 KO mice (C57/BL6J background) Conditional Flox/Cre (tet inducible) β-arrestin 2…

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B-arrestin biosensor cell lines

B-arrestin biosensor cell lines

Technology Duke inventors have created 14 novel biosensor cell lines that can be used for the detection of translocation events, generation of signaling messages, and protein-protein interactions within cells: U2OS-βarrestin2-YFP U2OS-βarrestin1-YFP 293-βarrestin2-YFP 293-βarrestin1-YFP NIH-3T3-Smo-GFP HEK293-rATlaR-CFP,…

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Plasmids for the expression of B-arrestins and GRKs

Plasmids for the expression of B-arrestins and GRKs

Technology Duke inventors have generated 12 novel plasmids that can be used for the expression of β-arrestins and GRKs: pCDNA3-βarrestin1-Flag pCDNA3-βarrestin2-Flag pGEX-5G/LIC-βarrestin1 pGEX-5G/LIC-βarrestin2 pGEX-4T1-βarrestin1 C-terminus pGEX-4T1-βarrestin2 C-terminus pRK5-bGRK2 pRK5-bGRK3 pRK5-bGRK4 pRK5-hGRK5 pRK5-hGRK6 pRK5-hGRK26caax

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Plasmids with RNA aptamers to B-arrestin

Plasmids with RNA aptamers to B-arrestin

Technology Duke inventors have created 10 novel plasmids which can be used for the production of RNA aptamers to β-arrestins through in vitro translation: pCR-TOPO-8R1-36 pCR-TOPO-8R2-1 pCR-TOPO-8R2-15 pCR-TOPO-8R2-16 pCR-TOPO-8R2-20 pCR-TOPO-8R2-21 pCR-TOPO-8R2-24 pCR-TOPO-11R2-5 pCR-TOPO-11R2-7 pCR-TOPO-11R2-15

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A mouse strain lacking functional GRK4 gene

A mouse strain lacking functional GRK4 gene

GRK4 is prominently expressed in testes, with expression also in select brain regions (cerebellum) and other organs and cell types. GRK4 has been implicated in regulation of cerebellar mGluRl and GABA, receptors, and may be…

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Hamster a1B-adrenergic receptor HeLa cell line

Hamster a1B-adrenergic receptor HeLa cell line

Technology Duke inventors have generated a human epithelial carcinoma (HeLa) cell line expressing the hamster α1B-adrenergic receptor.

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Rat a1A-adrenergic receptor HeLa cell line

Rat a1A-adrenergic receptor HeLa cell line

Technology Duke inventors have generated a human epithelial carcinoma (HeLa) cell line expressing the hamster α1B-adrenergic receptor.

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Human B2-adrenergic receptor CHW cell line

Human B2-adrenergic receptor CHW cell line

Technology Duke inventors have generated a chinese hamster fibroblast cell line that expresses the human β2–adrenegic receptor.

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Beta-arrestin inhibition to prevent S1P1 internalization as a treatment for intracranial diseases

Beta-arrestin inhibition to prevent S1P1 internalization as a treatment for intracranial diseases

Value Proposition Glioblastomas (GBMs) are among the most common and deadly malignant brain tumors with a mean survival time of approximately 14-15 months following diagnosis. Current treatments for GBMs include surgery, radiation, and chemotherapy, however,…

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