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Showing 2 matches for the following: Inventor: "Gross, Joshua" ×
Transgenic mouse strains to investigate biased ghrelin receptor (GHSR1a) drug candidates
Technology Duke inventors have created five novel transgenic mice with point, knockout, or humanizing mutations to the ghrelin receptor (GHSR1a): G protein-biased GHSR1a mouse (GHSR-P147A): CRISPR-Cas9 RNA-induced homology-directed repair (HDR) was used to create a…
A functionally selective ghrelin receptor (GHSR) ligand for treatment of chemical and food addiction
Unmet Need The number of Americans with addiction-related disorders, including substance use disorders (SUD) and food addiction is increasing rapidly each year. Recent estimates indicate that >20 million people in the U.S. have been diagnosed…