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Showing 13 matches for the following: Inventor: "Caron, Marc G" ×
Non-opioid treatment for chronic pain using a neurotensin receptor 1 modulator
Unmet Need For individuals experiencing chronic pain, day-to-day tasks and activities can become difficult or impossible. It can also lead to other long-term health challenges including insomnia, stress, anxiety, and depression. Chronic pain is so…
Use of sustained-release 5-hydroxytrypophan in treating constipation
Unmet Need Over 10% of the population suffers from constipation disorders, with irritable bowel syndrome-constipation and chronic idiopathic constipation being the most prevalent diagnoses. Current treatment options for constipation are available over-the-counter by prescription. However,…
System for detecting three protein-protein interactions in living cells
Unmet Need Recognizing Protein-Protein Interactions (PPIs) is central to many molecular biology studies aiming to identify important targets for the development of therapeutic drugs. There are thousands of PPIs that are essential to understand the…
Methods for identifying compounds that regulate beta-arrestin signaling complexes for use as antipsychotic drugs
Unmet Need About 35% of all drugs approved by the U.S. Food and Drug Administration target G protein-coupled receptors (GPCRs), a large and ubiquitous family of cell surface receptors with important contributions to neurological, hormonal,…
The use of arylcyclopropylamine inhibitors in the treatment of Parkinson’s disease
Value Proposition Treatment options for Parkinson’s disease are currently quite limited, and generally involve dopamine replacement therapy with a variety of dopaminergic agents. Levodopa (L-DOPA), the immediate precursor to dopamine, is currently the gold standard…
Activated caspase-3 reporter mouse
The activated caspase-3 reporter mouse is an in vivo screening assay for apoptosis (regulated, energy-dependent cell death) in all tissues. Fluorescence miscroscopy of the fluorophore mCerulean reveals levels of caspase-3 activation in cells, and hence…
Sequence of the gene and protein encoding the human D1 dopamine receptor
Value Proposition The Dopamine D1 receptor is known to regulate neuronal growth and development, in addition to playing important roles in learning and memory, locomotion, and other essential neural activities. Further investigation into its function…
A cDNA clone encoding a functional L-proline transporter expressed in rat brain
Value Proposition The L-proline transporter is expressed in several subpopulations of glutamatergic neurons and is implicated in higher cortical functions and memory. Several CNS disorders are associated with L-proline transporter abnormalities, and thus tools for…
An expressible antidepressant-sensitive serotonin transporter
Value Proposition Serotonin-targeting antidepressants are now prescribed for a wide spectrum of disorders, including obsessive-compulsive disorder, depression, as well as eating, sleep, and panic disorders. Next generation therapeutic strategies to combat these disorders, and to…
Mouse model of cholinergic dysfunction to evaluate cognitive enhancers for Alzheimer’s disease treatment
Value Proposition Defects in acetylcholine transmission have been associated with several major neurodegenerative disorders including Alzheimer’s disease, dementia, cerebral palsy, Parkinson’s disease, Huntington’s disease and myasthenia gravis. Although cholinergic dysfunction has been implicated in these…
Dopamine transporter knockout mouse
We have developed knockout mice lacking the dopamine transporter. These mice are hyperactive, and display cognitive abnormalities consistent with enhanced dopaminergic neurotransmission. They have a heightened dopaminergic state (increase dopamine activity), mimicking certain behaviors associated…
Norepinephrine transporter Knockout Mice
Duke University is seeking a company interested in commercializing a novel and versatile animal model of anti-depressant-related patients. Depression is the fourth leading contributor of disease worldwide with 18.8 million adult sufferers in the United…