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Showing 2 matches for the following: Inventor: "Beaulieu, Martin" ×
Methods for identifying compounds that regulate beta-arrestin signaling complexes for use as antipsychotic drugs
Unmet Need About 35% of all drugs approved by the U.S. Food and Drug Administration target G protein-coupled receptors (GPCRs), a large and ubiquitous family of cell surface receptors with important contributions to neurological, hormonal,…
Mice carrying functional single nucleotide polymorphisms in brain-specific trytophan hydroxylase(Tph2)
We have developed mice expressing 2 different mutant alleles of the brain-specific tryptophan hydroxylase gene (Tph2). Tryptophan hydroxylase is the rate limiting enzyme involved in the synthesis of serotonin. These mice have significantly reduced levels…