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Showing 7 matches for the following: Inventor: "Barak, Lawrence" ×

Therapy for neurotensin positive cancers

Therapy for neurotensin positive cancers

Unmet Need Under normal conditions, neurotensin signaling is largely constrained to the nervous system. However, abnormal expression is seen in cancers that are aggressive or have a poor prognosis such as pancreatic, which has a12.5%…

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Transgenic mouse strains to investigate biased ghrelin receptor (GHSR1a) drug candidates

Transgenic mouse strains to investigate biased ghrelin receptor (GHSR1a) drug candidates

Technology Duke inventors have created five novel transgenic mice with point, knockout, or humanizing mutations to the ghrelin receptor (GHSR1a): G protein-biased GHSR1a mouse (GHSR-P147A): CRISPR-Cas9 RNA-induced homology-directed repair (HDR) was used to create a…

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A functionally selective ghrelin receptor (GHSR) ligand for treatment of chemical and food addiction

A functionally selective ghrelin receptor (GHSR) ligand for treatment of chemical and food addiction

Unmet Need The number of Americans with addiction-related disorders, including substance use disorders (SUD) and food addiction is increasing rapidly each year. Recent estimates indicate that >20 million people in the U.S. have been diagnosed…

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Chemical modulators of immune checkpoints and cell growth for cancer treatment

Chemical modulators of immune checkpoints and cell growth for cancer treatment

Unmet Need Each year there are over 1.6 million new cases of cancer in the US, and over 600,000 cases prove fatal. Treating various types of cancer can be particularly challenging because of the complex…

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Non-opioid treatment for chronic pain using a neurotensin receptor 1 modulator

Non-opioid treatment for chronic pain using a neurotensin receptor 1 modulator

Unmet Need For individuals experiencing chronic pain, day-to-day tasks and activities can become difficult or impossible. It can also lead to other long-term health challenges including insomnia, stress, anxiety, and depression. Chronic pain is so…

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A screening library of more than 40 GPCR cell lines and/or corresponding plasmids for enabling addiction research

A screening library of more than 40 GPCR cell lines and/or corresponding plasmids for enabling addiction research

Unmet Need Addiction is a health concern costing the country in both dollars and human resources. The realization that addictive behavior is a consequence of signaling disorders in the brain, and thus reflects a disease…

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Novel mutation-resistant smoothened inhibitors for cancer therapy

Novel mutation-resistant smoothened inhibitors for cancer therapy

Value Proposition The hedgehog signaling pathway is an important mediator of developmental and cellular differentiation processes in both embryonic and adult tissues, but can also promote tumor growth and progression if dysregulated. Two forms of…

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