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A mouse strain lacking functional GRK4 gene

A mouse strain lacking functional GRK4 gene

GRK4 is prominently expressed in testes, with expression also in select brain regions (cerebellum) and other organs and cell types. GRK4 has been implicated in regulation of cerebellar mGluRl and GABA, receptors, and may be…

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Dopamine transporter knockout mice as a screening tool for anti-parkinsonian and anti-dyskinetic agents

Dopamine transporter knockout mice as a screening tool for anti-parkinsonian and anti-dyskinetic agents

Unmet Need The dopamine precursor L-DOPA is the primary treatment for Parkinson's Disease (PD). However, in addition to alleviating motor deficits associated with PD, 50-90% of patients experience side effects such as dyskinesia after 5-10…

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Transgenic zebrafish with hand2 tagged with GFP

Transgenic zebrafish with hand2 tagged with GFP

Technology Duke inventors have generated transgenic zebrafish with the native hand2 developmental transcription factor tagged with green fluorescent protein (GFP). This allows visualization of the activation of hand2 regulatory sequences and can be used for…

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Activated caspase-3 reporter mouse

Activated caspase-3 reporter mouse

Technology The activated caspase-3 reporter mouse is an in vivo screening assay for apoptosis (regulated, energy-dependent cell death) in all tissues. Fluorescence miscroscopy of the fluorophore mCerulean reveals levels of caspase-3 activation in cells, and…

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Transgenic mouse strains to investigate biased ghrelin receptor (GHSR1a) drug candidates

Transgenic mouse strains to investigate biased ghrelin receptor (GHSR1a) drug candidates

Technology Duke inventors have created five novel transgenic mice with point, knockout, or humanizing mutations to the ghrelin receptor (GHSR1a): G protein-biased GHSR1a mouse (GHSR-P147A): CRISPR-Cas9 RNA-induced homology-directed repair (HDR) was used to create a…

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Human B2-adrenergic receptor CHW cell line

Human B2-adrenergic receptor CHW cell line

Technology Duke inventors have generated a chinese hamster fibroblast cell line that expresses the human β2–adrenegic receptor.

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Cell line expressing chimeric Tie2 receptors

Cell line expressing chimeric Tie2 receptors

Technology Duke inventors have generated a cell line that expresses chimeric Tie2 receptors. Specifically, NIH 3T3 cells were infected with retroviruses containing a plasmid that encoded the extracellular and transmembrain domains of the c-fms receptor…

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An induced pluripotent stem cell model of Duchenne muscular dystrophy

An induced pluripotent stem cell model of Duchenne muscular dystrophy

Unmet Need Duchenne muscular dystrophy (DMD) is a rare genetic disease that causes the skeletal and heart muscles to weaken. Due to a mutation in dystrophin, an important protein involved in muscle structure, individuals with…

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Human cell line lacking both Dicer and PKR

Human cell line lacking both Dicer and PKR

Technology Duke inventors have created a human cell line that lacks functional dcr and pkr genes. Specifically, the HEK293T cells, a human cell line with a mutated dcr gene was modified using the CRISPR/Cas9 system…

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VMAT2 heterozygous mouse line as a model of brain dysfunction associated with behavioral deficits

VMAT2 heterozygous mouse line as a model of brain dysfunction associated with behavioral deficits

Technology Duke inventors have developed a novel mouse model that is heterozygous for vesicular monoamine transport 2 (VMAT2), a protein located in the central nervous system that transports monoamines such as dopamine and serotonin from…

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Long extra-corporeal arterial sheaths and catheters for coronary angiography and intervention

Long extra-corporeal arterial sheaths and catheters for coronary angiography and intervention

Value Proposition Percutaneous coronary interventions (PCI) such as angioplasty and angiography can be performed for therapeutic as well as diagnostic reasons. Over 20 million angiography and 10 million angioplasty procedures are projected to be performed…

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Pancreatic cancer treatment that inhibits the Piezo1/TRPV4 axis

Pancreatic cancer treatment that inhibits the Piezo1/TRPV4 axis

Unmet Need Pancreatic cancer has one of the highest mortality rates of all cancer types in the US. The American Cancer Society predicts that about 64,000 people will be diagnosed with pancreatic cancer and 55,000…

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