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Improving the efficacy of anti-PD-1 antibody immunotherapy
Value Proposition Despite the significant impact that the checkpoint inhibitor immunotherapies have generated in clinical oncology, the majority of our cancer patients still do not benefit from this treatment modality. While the PD-1/PD-L1 system plays…
Rapid immunoassay to detect anti-EGFRviii levels to evaluate vaccine efficacy
Value Proposition Tumor-specific molecules offer the possibility of targeted cancer therapy using monoclonal antibodies (mAbs) specifically directed against the tumor-specific molecule. However, it has proven difficult to identify tumor-specific molecules. Overexpression of EGFR in human…
Drug diversion surveillance dashboard
Value Proposition Prescription drug diversion is defined as the illegal distribution or misuse of prescription medications. Drugs that are susceptible to abuse and addiction in at-risk individuals are commonly involved. In the light of nationwide…
Mining microbial genomes for biologically active compounds
Most microbes of importance to human and environmental health are not amenable to experimentation. As a result, we do not know what molecules these microbes use to manipulate their environment- many of which are likely…
A universal antidote for aptamer therapeutics
Value Proposition With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to…
Gene therapy for Crb1 retinopathies
Value Proposition Current treatments for retinal disease include laser surgeries, injectable corticosteroids, and other medications which may slow the process of retinal degeneration but are not able to stop it. The Crb1 protein has been…
Whole eye optical coherence tomography scanner
Value proposition Optical Coherence Tomography (OCT) is an Optical imaging technique that provides 3D images of the subject of interest. OCT systems have been widely used to scan eyes for medical purposes. However, commercial OCT…
Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions
Value Proposition Proteins can be useful therapeutic agents when engineered for specificity and selectivity for a clinical target. Their complexity, versatility, tolerability, and diversity often make them superior alternatives to small molecule drugs, and the…
Improving visualization during ultrasound-guided needle insertions
Value Proposition Insertion of needles into blood vessels is a common and crucial intervention for insertion of venous and arterial catheters, as well as blood sampling. Similarly, insertion of needles into tumors and other tissues…
Components of the Wnt-Beta-catenin paracrine signaling pathway as predictive biomarkers for cancer immunotherapy
Value Proposition Immunotherapy is a promising approach for the treatment of many cancers. However, despite early success, majority of patients with advanced cancer fail to respond or become resistant. In even the most immunogenic cancer…
A deep machine learning algorithm to aid the diagnosis of cardiac transplant rejection
Value Proposition Transplant rejection remains a significant clinical concern following solid organ transplants, including cardiac transplantation. Although endomyocardial biopsy to diagnose cardiac allograft rejection is the gold standard of histologic grading of biopsy samples for…
RealChoices web-based menu planning and nutrition tracking computer software program
Value Proposition There are variable reasons why someone would seek a heathier food-related lifestyle. Unhealthy eating habits can have serios negative effects in one’s health. In America alone, it is estimated that over two-thirds of…